Document Detail

The site of action of furosemide.
MedLine Citation:
PMID:  9642037     Owner:  NLM     Status:  MEDLINE    
To establish whether furosemide (F) acts on the proximal tubule beside the thick ascending limb of Henle's loop, we reviewed the data from 55 rats studied before and during the i.v. infusion of 10 mg kg-1 of furosemide. These animals were the object of previously published studies. SNGFR was 42.6+/-1.1 nl min-1 during baseline conditions (B), 42.7 nl min-1 during F (P>0.9). In 151 paired last proximal tubular samples, percentage reabsorption was 71.72 before and 71.72% after F (P=1.0). In 64 paired early distal tubular samples, percent reabsorption fell from 86% in B to 78% during F (P<0.0001). During F, the urine flow rate expressed as a percentage of GFR (24+/-2%) was significantly correlated (R=0.52, P<0.0001) with the percent delivery of filtrate out of the proximal tubule (26+/-3%). These data demonstrate that, even at this very high dosage, F does not act on the proximal tubule. It inhibits transport on the ascending limb of Henle's loop. By allowing the delivery of isotonic tubular fluid to the distal tubule, it causes a fall in volume absorption along the early distal convolution in proportion to its baseline water permeability. It increases urine flow by abolishing the interstitial hypertonicity and, consequently, the osmotically driven solvent flow across the distal epithelium and collecting ducts. Therefore the urine flow rate during F closely approximates volume delivery out of the proximal tubule.
G Romano; G Favret; E Federico; E Bartoli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Pharmacological research : the official journal of the Italian Pharmacological Society     Volume:  37     ISSN:  1043-6618     ISO Abbreviation:  Pharmacol. Res.     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-08-06     Completed Date:  1998-08-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8907422     Medline TA:  Pharmacol Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  409-19     Citation Subset:  IM    
Copyright Information:
Copyright 1998 The Italian Pharmacological Society.
Polilinico Universitario, Piazzale Santa Maria della Misericordia 1, Udine, 33100, Italy.
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MeSH Terms
Diuretics / pharmacology*
Furosemide / pharmacology*
Glomerular Filtration Rate / drug effects
Kidney Tubules, Proximal / drug effects*
Loop of Henle / drug effects
Reg. No./Substance:
0/Diuretics; 54-31-9/Furosemide

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