| The sinus node inhibitor UL-FS 49 lacks significant inotropic effect. | |
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MedLine Citation:
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PMID: 1376796 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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UL-FS 49 is a sinus node inhibitor that has been reported to reduce heart rate and may be useful in improving myocardial oxygen supply vs. demand. However, previous studies performed in a variety of preparations have produced mixed results regarding the independent inotropic effect of UL-FS 49. To determine whether UL-FS 49 has an inotropic effect, we measured both steady-state hemodynamic responses and transient hemodynamic responses to random preload and afterload changes, both with and without UL-FS 49. We found that under steady-state conditions, the effect of UL-FS 49 is so small that it would be of doubtful physiologic significance: a 3% increase in stroke volume (p = 0.007) and 7% increase in peak positive dP/dt (p = 0.051), in the presence of no statistically significant differences in end-diastolic pressure, end-diastolic volume, peak systolic pressure, end-systolic pressure, or heart rate. The more powerful multiple linear regression modeling of hemodynamic transient sequences resulting from random preload and afterload changes showed that UL-FS 49 is without a statistically significant direct effect on left ventricular function. We conclude that UL-FS 49 has no physiologically important direct effect on left ventricular pump function. |
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Authors:
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Z Y Chen; B K Slinker |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: 19 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 1992 Feb |
Date Detail:
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Created Date: 1992-07-21 Completed Date: 1992-07-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 264-71 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Vermont, Burlington. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Animals Benzazepines / administration & dosage, pharmacology* Cardiovascular Agents / administration & dosage, pharmacology* Dogs Female Hemodynamics / drug effects Male Myocardial Contraction / drug effects* Stimulation, Chemical Ventricular Function, Left / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL-37005/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Benzazepines; 0/Cardiovascular Agents; 85175-67-3/zatebradine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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