| A single testing of serum amyloid a levels as a tool for diagnosis and treatment dilemmas in familial Mediterranean fever. | |
| | |
MedLine Citation:
|
PMID: 17512038 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: In a significant proportion of patients with familial Mediterranean fever (FMF), serum amyloid A (SAA) remains elevated during attack-free periods, thereby increasing the risk of developing amyloidosis. The aim of the study was to determine various correlates of elevated SAA and evaluate the role of SAA measurement in the diagnosis and management of FMF. METHODS: We reviewed the medical files of all 204 patients from our FMF center in whom SAA measurements were performed. SAA levels and the resulting diagnostic and therapeutic decisions were analyzed in relation to the reasons of SAA testing and to several clinical and genetic parameters. RESULTS: SAA measurements were made for diagnostic purposes in 29% of the patients. In the remainder, SAA measurements were used for adjustment of colchicine dose. Elevated SAA levels are found in a third of FMF patients during an attack-free period. The highest rate of elevated SAA levels was found in patients with proteinuria (60% of this patient group), followed by noncompliant (40%) and genetically positive asymptomatic patients (38%). Elevated SAA levels during remission were associated with family history of FMF, M694V homozygosity, and elevated C-reactive protein (CRP) (P<0.05 for each). Patients homozygous for the M694V mutation had the highest level of SAA. SAA measurement led to a change in colchicine dose in 30% of the patients, predominantly in noncompliant patients and patients with proteinuria or with atypical manifestations. CONCLUSIONS: Measurement of SAA level may help in the diagnosis of FMF and in adjustment of the colchicine dose. |
| | |
Authors:
|
Yackov Berkun; Shai Padeh; Brian Reichman; Nurit Zaks; Einat Rabinovich; Merav Lidar; Bracha Shainberg; Avi Livneh |
Related Documents
:
|
17050638 - Factors involved in vascular calcification and atherosclerosis in maintenance haemodial... 12204808 - C-reactive protein and multiple complex coronary artery plaques in patients with primar... 18535598 - C-reactive protein levels do not correlate with retinal artery occlusion but with ather... 16409458 - C-reactive protein contributes to the hypercoagulable state in coronary artery disease. 22888438 - Shifting up cutoff value of d-dimer in the evaluation of pulmonary embolism: a viable o... 16885178 - Oesophageal dysmotility in systemic sclerosis: comparison of hrct and scintigraphy. |
Publication Detail:
|
Type: Journal Article Date: 2007-05-23 |
Journal Detail:
|
Title: Seminars in arthritis and rheumatism Volume: 37 ISSN: 0049-0172 ISO Abbreviation: Semin. Arthritis Rheum. Publication Date: 2007 Dec |
Date Detail:
|
Created Date: 2007-11-30 Completed Date: 2008-02-21 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 1306053 Medline TA: Semin Arthritis Rheum Country: United States |
Other Details:
|
Languages: eng Pagination: 182-8 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, Safra Children's Hospital, Sheba Medical Center, Tel-Hashomer, Israel. berkun@md.huji.ac.il |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Biological Markers / blood Colchicine / administration & dosage* Drug Monitoring Familial Mediterranean Fever / blood, diagnosis*, drug therapy*, genetics Female Follow-Up Studies Genotype Humans Male Patient Compliance Point Mutation Serum Amyloid A Protein / genetics*, metabolism* Tubulin Modulators / administration & dosage* |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/Serum Amyloid A Protein; 0/Tubulin Modulators; 64-86-8/Colchicine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Study of the impact of land use and hydrogeological settings on the shallow groundwater quality in a...
Next Document: Erik von Willebrand.