| A single sub-anaesthetic dose of propofol to reduce patient recall of peribulbar block. | |
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MedLine Citation:
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PMID: 11143688 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We audited a total of 1233 patients scheduled for elective cataract extraction or trabeculectomy using peri-bulbar anaesthesia. A bolus of propofol provided sedation to cover insertion of the block. During an initial two-year period we collected data on the amount of propofol used to sedate 481 patients. Multiple linear regression analysis was then used to obtain an equation to link the dose used to age and weight in those who were adequately sedated. The dose of propofol in milligrams was calculated as 56 + 0.25 x weight (kg) - 0.53 x age (yrs). We subsequently assessed the effectiveness of this formula at abolishing recall of the injections whilst not compromising the airway on a further 752 patients. This simple regime was effective at abolishing recall of the block in 78.6% of the patients studied and avoids the cost and logistic implications of more complicated drug delivery systems. Use of the formula does not significantly alter the incidence of recall compared to sedation provided by an experienced ophthalmic anaesthetist. We hope it will provide a guide for more junior anaesthetists to obtain the satisfactory sedation level that comes with experience. |
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Authors:
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G Hocking; H G Balmer |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Journal of the Royal Army Medical Corps Volume: 146 ISSN: 0035-8665 ISO Abbreviation: J R Army Med Corps Publication Date: 2000 Oct |
Date Detail:
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Created Date: 2000-12-19 Completed Date: 2001-02-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7505627 Medline TA: J R Army Med Corps Country: England |
Other Details:
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Languages: eng Pagination: 196-8 Citation Subset: IM |
Affiliation:
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Department of Anaesthesia, MDHU Frimley Park Hospital, Frimley, Camberley, Surrey, GU16 5UJ. drghocking@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Aged Anesthetics, Intravenous / administration & dosage*, pharmacology Anesthetics, Local Body Weight Bupivacaine Cataract Extraction / adverse effects* Female Humans Hypnotics and Sedatives / administration & dosage*, pharmacology Injections, Intravenous Lidocaine Linear Models Male Medical Audit Mental Recall / drug effects* Nerve Block / methods* Propofol / pharmacology, therapeutic use* Prospective Studies Sex Characteristics Trabeculectomy / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Intravenous; 0/Anesthetics, Local; 0/Hypnotics and Sedatives; 137-58-6/Lidocaine; 2078-54-8/Propofol; 2180-92-9/Bupivacaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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