| A single session of haemodialysis improves left ventricular synchronicity in patients with end-stage renal disease: a pilot tissue synchronization imaging study. | |
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MedLine Citation:
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PMID: 18556749 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Mechanical left ventricular (LV) dyssynchrony impairs cardiac function in patients with heart failure and LV hypertrophy (LVH) and may be a factor contributing to the high incidence of cardiac deaths in patients with end-stage renal disease (ESRD). Objectives. To evaluate the possible presence of LV dyssynchrony in ESRD patients, and acute effect of haemodialysis (HD) on LV synchronicity using a tailored echocardiographic modality, tissue synchronization imaging (TSI). METHODS: In 13 clinically stable ESRD patients (7 men; 65 +/- 10 years) with LVH, echocardiography data were acquired before and after a single HD session for subsequent off-line TSI analysis enabling the retrieval of regional intraventricular systolic delay data. Six basal and six midventricular LV segments were evaluated. Dyssynchrony was defined as a regional difference in time to peak systolic velocity >105 ms. RESULTS: Before HD, all patients had at least one dyssynchronous LV segment. The percentage of delayed segments correlated positively to LV end-diastolic diameter (r = 0.68, P < 0.05). HD induced a substantial decrease in the percentage of delayed segments from 36 +/- 25% to 19 +/- 14% (P < 0.01), reduced average maximal mechanical systolic LV delay from 300 +/- 89 to 225 +/- 116 ms (P < 0.05) and completely normalized LV synchronicity in three patients (23%). CONCLUSIONS: LV dyssynchrony appears to be present frequently in ESRD patients with LVH. The severity of LV dyssynchrony correlates with LV end-diastolic diameter and decreases after a single session of HD suggesting a mechanistic relevance of volume overload and possibly other toxins accumulating in HD patients. |
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Authors:
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Shirley Yumi Hayashi; Astrid Seeberger; Britta Lind; Jacek Nowak; Marcelo Mazza do Nascimento; Bengt Lindholm; Lars-Ake Brodin |
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Publication Detail:
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Type: Clinical Trial; Journal Article Date: 2008-06-13 |
Journal Detail:
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Title: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Volume: 23 ISSN: 1460-2385 ISO Abbreviation: Nephrol. Dial. Transplant. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-10-16 Completed Date: 2009-03-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8706402 Medline TA: Nephrol Dial Transplant Country: England |
Other Details:
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Languages: eng Pagination: 3622-8 Citation Subset: IM |
Affiliation:
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Department of Medical Engineering, School of Technology and Health, Royal Institute of Technology, Karolinska Institutet, Karolinska University Hospital in Huddinge, Stockholm, Sweden. shirley.yumi.hayashi@ki.se |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Echocardiography Female Heart Ventricles / physiopathology, ultrasonography Humans Hypertrophy, Left Ventricular / etiology, physiopathology*, therapy* Kidney Failure, Chronic / complications, physiopathology*, therapy* Male Middle Aged Pilot Projects Renal Dialysis* Treatment Outcome Ventricular Dysfunction, Left / etiology, physiopathology*, therapy* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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