Document Detail

A single question for the rapid screening of restless legs syndrome in the neurological clinical practice.
MedLine Citation:
PMID:  17718694     Owner:  NLM     Status:  MEDLINE    
The purposes of this study were to validate the use of a single standard question for the rapid screening of restless legs syndrome (RLS) and to analyze the eventual effects of the presence of RLS on self-assessed daytime sleepiness, global clinical severity and cognitive functioning. We evaluated a group of 521 consecutive patients who accessed our neurology clinic for different reasons. Beside the answer to the single question and age, sex, and clinical diagnosis, the following items were collected from all patients and normal controls: the four criteria for RLS, the Epworth Sleepiness Scale (ESS), the Clinical Global Impression of Severity (CGI-S), and the Mini-Mental State evaluation. RLS was found in 112 patients (70 idiopathic). The single question had 100% sensitivity and 96.8% specificity for the diagnosis of RLS. ESS and CGI-S were significantly higher in both RLS patient groups than in normal controls. RLS severity was significantly higher in idiopathic than in associated/symptomatic RLS patients. RLS can be screened with high sensitivity and good reliability in large patient groups by means of the single question; however, the final diagnosis should always be confirmed by the diagnostic features of RLS and accompanied by a careful search for comorbid conditions.
R Ferri; B Lanuzza; F I I Cosentino; I Iero; M Tripodi; R S Spada; G Toscano; S Marelli; D Aricò; R Bella; W A Hening; M Zucconi
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Publication Detail:
Type:  Journal Article; Validation Studies    
Journal Detail:
Title:  European journal of neurology : the official journal of the European Federation of Neurological Societies     Volume:  14     ISSN:  1468-1331     ISO Abbreviation:  Eur. J. Neurol.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-27     Completed Date:  2007-09-26     Revised Date:  2009-02-27    
Medline Journal Info:
Nlm Unique ID:  9506311     Medline TA:  Eur J Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1016-21     Citation Subset:  IM    
Sleep Research Centre, Department of Neurology I.C., Oasi Institute for Research on Mental Retardation and Brain Aging (IRCCS), Troina, Italy.
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MeSH Terms
Aged, 80 and over
Mass Screening*
Middle Aged
Predictive Value of Tests
Reproducibility of Results
Restless Legs Syndrome / diagnosis*,  physiopathology*
Sensitivity and Specificity
Severity of Illness Index
Comment In:
Eur J Neurol. 2007 Sep;14(9):951   [PMID:  17718685 ]
Nat Clin Pract Neurol. 2008 Mar;4(3):132-3   [PMID:  18253101 ]

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