| A single promoter inversion switches Photorhabdus between pathogenic and mutualistic states. | |
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MedLine Citation:
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PMID: 22767929 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Microbial populations stochastically generate variants with strikingly different properties, such as virulence or avirulence and antibiotic tolerance or sensitivity. Photorhabdus luminescens bacteria have a variable life history in which they alternate between pathogens to a wide variety of insects and mutualists to their specific host nematodes. Here, we show that the P. luminescens pathogenic variant (P form) switches to a smaller-cell variant (M form) to initiate mutualism in host nematode intestines. A stochastic promoter inversion causes the switch between the two distinct forms. M-form cells are much smaller (one-seventh the volume), slower growing, and less bioluminescent than P-form cells; they are also avirulent and produce fewer secondary metabolites. Observations of form switching by individual cells in nematodes revealed that the M form persisted in maternal nematode intestines, were the first cells to colonize infective juvenile (IJ) offspring, and then switched to P form in the IJ intestine, which armed these nematodes for the next cycle of insect infection. |
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Authors:
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Vishal S Somvanshi; Rudolph E Sloup; Jason M Crawford; Alexander R Martin; Anthony J Heidt; Kwi-suk Kim; Jon Clardy; Todd A Ciche |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 337 ISSN: 1095-9203 ISO Abbreviation: Science Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-07-06 Completed Date: 2012-07-23 Revised Date: 2013-02-14 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: United States |
Other Details:
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Languages: eng Pagination: 88-93 Citation Subset: IM |
Affiliation:
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Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GEO/GSE32088 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Fimbriae Proteins / genetics Gene Expression Regulation, Bacterial Genome, Bacterial Intestines / microbiology Moths / microbiology* Mutation Phenotype Photorhabdus / cytology, genetics*, growth & development, pathogenicity* Promoter Regions, Genetic* Rhabditoidea / microbiology* Sequence Inversion* Symbiosis* Virulence / genetics |
| Grant Support | |
ID/Acronym/Agency:
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1K99 GM097096-01/GM/NIGMS NIH HHS; R00 GM097096/GM/NIGMS NIH HHS; R01 GM086258/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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147680-16-8/Fimbriae Proteins |
| Comments/Corrections | |
Comment In:
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Nat Rev Microbiol. 2012 Sep;10(9):594-5
[PMID:
22820923
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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