Document Detail


A single promoter inversion switches Photorhabdus between pathogenic and mutualistic states.
MedLine Citation:
PMID:  22767929     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Microbial populations stochastically generate variants with strikingly different properties, such as virulence or avirulence and antibiotic tolerance or sensitivity. Photorhabdus luminescens bacteria have a variable life history in which they alternate between pathogens to a wide variety of insects and mutualists to their specific host nematodes. Here, we show that the P. luminescens pathogenic variant (P form) switches to a smaller-cell variant (M form) to initiate mutualism in host nematode intestines. A stochastic promoter inversion causes the switch between the two distinct forms. M-form cells are much smaller (one-seventh the volume), slower growing, and less bioluminescent than P-form cells; they are also avirulent and produce fewer secondary metabolites. Observations of form switching by individual cells in nematodes revealed that the M form persisted in maternal nematode intestines, were the first cells to colonize infective juvenile (IJ) offspring, and then switched to P form in the IJ intestine, which armed these nematodes for the next cycle of insect infection.
Authors:
Vishal S Somvanshi; Rudolph E Sloup; Jason M Crawford; Alexander R Martin; Anthony J Heidt; Kwi-suk Kim; Jon Clardy; Todd A Ciche
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  337     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-06     Completed Date:  2012-07-23     Revised Date:  2014-05-09    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  88-93     Citation Subset:  IM    
Data Bank Information
Bank Name/Acc. No.:
GEO/GSE32088
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MeSH Terms
Descriptor/Qualifier:
Animals
Fimbriae Proteins / genetics
Gene Expression Regulation, Bacterial
Genome, Bacterial
Intestines / microbiology
Moths / microbiology*
Mutation
Phenotype
Photorhabdus / cytology,  genetics*,  growth & development,  pathogenicity*
Promoter Regions, Genetic*
Rhabditoidea / microbiology*
Sequence Inversion*
Symbiosis*
Virulence / genetics
Grant Support
ID/Acronym/Agency:
1K99 GM097096-01/GM/NIGMS NIH HHS; K99 GM097096/GM/NIGMS NIH HHS; R00 GM097096/GM/NIGMS NIH HHS; R01 GM086258/GM/NIGMS NIH HHS; R01 GM086258/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
147680-16-8/Fimbriae Proteins
Comments/Corrections
Comment In:
Nat Rev Microbiol. 2012 Sep;10(9):594-5   [PMID:  22820923 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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