Document Detail


The single place fields of CA3 cells: a two-stage transformation from grid cells.
MedLine Citation:
PMID:  20928834     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Granule cells of the dentate gyrus (DG) generally have multiple place fields, whereas CA3 cells, which are second order, have only a single place field. Here, we explore the mechanisms by which the high selectivity of CA3 cells is achieved. Previous work showed that the multiple place fields of DG neurons could be quantitatively accounted for by a model based on the number and strength of grid cell inputs and a competitive network interaction in the DG that is mediated by gamma frequency feedback inhibition. We have now built a model of CA3 based on similar principles. CA3 cells receive input from an average of one active DG cell and from 1,400 cortical grid cells. Based on experimental findings, we have assumed a linear interaction of the two pathways. The results show that simulated CA3 cells generally have a single place field, as observed experimentally. Thus, a two-step process based on simple rules (and that can occur without learning) is able to explain how grid cell inputs to the hippocampus give rise to cells having ultimate spatial selectivity. The CA3 processes that produce a single place depend critically on the competitive network processes and do not require the direct cortical inputs to CA3, which are therefore likely to perform some other unknown function.
Authors:
Licurgo de Almeida; Marco Idiart; John E Lisman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-10-06
Journal Detail:
Title:  Hippocampus     Volume:  22     ISSN:  1098-1063     ISO Abbreviation:  Hippocampus     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-19     Completed Date:  2012-05-14     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  9108167     Medline TA:  Hippocampus     Country:  United States    
Other Details:
Languages:  eng     Pagination:  200-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Wiley Periodicals, Inc.
Affiliation:
Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA.
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MeSH Terms
Descriptor/Qualifier:
CA3 Region, Hippocampal / physiology*
Computer Simulation*
Models, Neurological*
Pyramidal Cells / physiology*
Grant Support
ID/Acronym/Agency:
P50 MH060450/MH/NIMH NIH HHS; P50 MH060450/MH/NIMH NIH HHS; R01 DA027807/DA/NIDA NIH HHS; R01DA027807/DA/NIDA NIH HHS
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