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A single nucleotide polymorphism in the dopamine receptor d2 gene may be informative for resistance to fescue toxicosis in angus-based cattle.
MedLine Citation:
PMID:  24299180     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Fescue toxicosis (FT) reduces beef animal growth and fertility. Animals afflicted with FT typically have decreased circulating prolactin concentrations and thicker summer hair coats. Preliminary experiments examined the informativeness of a novel Dopamine Receptor 2 (DRD2) G/A SNP for resistance to FT. Steers grazed tall fescue containing a toxic (E+) or non-toxic (NTE) strain of endophyte. Decreased serum prolactin concentrations were observed in GG steers in May compared to AA steers when grazing E+ pastures (P < 0.02). In a second study, GG steers had decreased prolactin concentrations (P = 0.004) and increased hair coat scores (P = 0.01) relative to AA steers when grazing E+ pastures. Allele and genotypic frequencies were different (P = 0.016 and 0.026, respectively) between spring-calving and fall-calving herds grazing E+ pastures, such that the A allele and the AA genotype were more prevalent in spring-calving herds, suggesting active selection for the A allele. Regardless of calving season, AA heifers tended toward fewer days to first calf (733.6 ± 4.4 d) than did GG heifers (756.6 ± 9.2 days; P = 0.055). These results suggest that the DRD2 SNP may have use in selecting animals resistant to FT.
Authors:
B T Campbell; C J Kojima; T A Cooper; B C Bastin; L Wojakiewicz; R L Kallenbach; F N Schrick; J C Waller
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Animal biotechnology     Volume:  25     ISSN:  1532-2378     ISO Abbreviation:  Anim. Biotechnol.     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2013-12-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9011409     Medline TA:  Anim Biotechnol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1-12     Citation Subset:  IM    
Affiliation:
a Department of Animal Science , University of Tennessee , Knoxville , Tennessee , USA.
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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