Document Detail

A single night time dose of ranitidine in the acute treatment of gastric ulcer: a European multicentre trial.
MedLine Citation:
PMID:  3525337     Owner:  NLM     Status:  MEDLINE    
Four hundred and twenty eight patients with endoscopically diagnosed gastric ulcers, randomly allocated to treatment with ranitidine 300 mg at night or ranitidine 150 mg twice daily, were evaluated in a double blind multicentre trial conducted in 10 European countries. After four weeks, complete ulcer healing was observed in 138 of 211 patients (65%) treated with ranitidine 300 mg nocte and in 155 of 217 patients (71%) receiving 150 mg bd. Cumulative healing rates at eight weeks were 90% and 93%, respectively. There was no statistically significant difference between the healing rates at either four or eight weeks. The treatment regimens were equally effective at rapidly reducing the incidence of ulcer related symptoms. Adverse events reported were minor and equally distributed between the two groups. The results of this trial show that 300 mg of ranitidine administered at night is an effective and safe alternative to the current twice daily regimen for the short term treatment of gastric ulcer.
F P Ryan; R Jorde; R S Ehsanullah; K Summers; J R Wood
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Gut     Volume:  27     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1986 Jul 
Date Detail:
Created Date:  1986-09-17     Completed Date:  1986-09-17     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  784-8     Citation Subset:  AIM; IM    
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MeSH Terms
Administration, Oral
Clinical Trials as Topic
Double-Blind Method
Middle Aged
Random Allocation
Ranitidine / administration & dosage*,  therapeutic use
Stomach Ulcer / drug therapy*
Reg. No./Substance:

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