Document Detail


A single major chromosomal region controls natural killer cell-like activity in rainbow trout.
MedLine Citation:
PMID:  14968267     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report the identification of a single major chromosomal region controlling natural killer (NK) cell-like activity in rainbow trout (Oncorhynchus mykiss). A genetic map based on 484 AFLP and 39 microsatellite genotypes from 106 doubled haploid fish was constructed. These fish were produced by androgenesis from a hybrid of two clonal lines divergent in NK-like activity. NK-like activities for 75 of the doubled haploids were quantified by an in vitro chromium release assay utilizing (51)Cr-labeled YAC-1 target cells. Composite interval mapping revealed a single major quantitative trait locus (QTL) associated with NK-like activity in this rainbow trout model. Genetic mapping revealed this QTL to also be unlinked to: fragmented MHC class I and MHC class II regions, the leukocyte receptor cluster, the natural killer cell enhancement factor ( NKEF) gene, the RAG-1 gene, and two QTL associated with resistance to infectious pancreatic necrosis virus in rainbow trout. Collectively, these results extend the utility of rainbow trout as an immunological model and are consistent with the idea that a single chromosomal region homologous to the natural killer cell complex (NKC) located on syntenic portions of mouse chromosome (Chr) 6, human Chr 12, and rat Chr 4 may exist in a lower vertebrate model.
Authors:
Anastasia M Zimmerman; Jason P Evenhuis; Gary H Thorgaard; Sandra S Ristow
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2004-02-17
Journal Detail:
Title:  Immunogenetics     Volume:  55     ISSN:  0093-7711     ISO Abbreviation:  Immunogenetics     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-03-26     Completed Date:  2004-05-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0420404     Medline TA:  Immunogenetics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  825-35     Citation Subset:  IM    
Affiliation:
Department of Animal Sciences, Washington State University, Pullman, WA 99164-6332, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chromium / metabolism
Chromosome Mapping*
Chromosomes / genetics*
Female
Genotype
Haploidy
Histocompatibility Antigens Class I / genetics,  immunology
Killer Cells, Natural / immunology*
Lod Score
Male
Microsatellite Repeats
Oncorhynchus mykiss / genetics*
Polymorphism, Restriction Fragment Length
Quantitative Trait, Heritable*
Chemical
Reg. No./Substance:
0/Histocompatibility Antigens Class I; 7440-47-3/Chromium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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