Document Detail

A single early introduction of HIV-1 subtype B into Central America accounts for most current cases.
MedLine Citation:
PMID:  23616665     Owner:  NLM     Status:  MEDLINE    
Human immunodeficiency virus type 1 (HIV-1) variants show considerable geographical separation across the world, but there is limited information from Central America. We provide the first detailed investigation of the genetic diversity and molecular epidemiology of HIV-1 in six Central American countries. Phylogenetic analysis was performed on 625 HIV-1 pol gene sequences collected between 2002 and 2010 in Honduras, El Salvador, Nicaragua, Costa Rica, Panama, and Belize. Published sequences from neighboring countries (n = 57) and the rest of the world (n = 740) were included as controls. Maximum likelihood methods were used to explore phylogenetic relationships. Bayesian coalescence-based methods were used to time HIV-1 introductions. Nearly all (98.9%) Central American sequences were of subtype B. Phylogenetic analysis revealed that 437 (70%) sequences clustered within five significantly supported monophyletic clades formed essentially by Central American sequences. One clade contained 386 (62%) sequences from all six countries; the other four clades were smaller and more country specific, suggesting discrete subepidemics. The existence of one large well-supported Central American clade provides evidence that a single introduction of HIV-1 subtype B in Central America accounts for most current cases. An introduction during the early phase of the HIV-1 pandemic may explain its epidemiological success. Moreover, the smaller clades suggest a subsequent regional spread related to specific transmission networks within each country.
Wendy Murillo; Nazle Veras; Mattia Prosperi; Ivette Lorenzana de Rivera; Gabriela Paz-Bailey; Sonia Morales-Miranda; Sandra I Juarez; Chunfu Yang; Joshua DeVos; José Pablo Marín; Mattias Mild; Jan Albert; Marco Salemi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-04-24
Journal Detail:
Title:  Journal of virology     Volume:  87     ISSN:  1098-5514     ISO Abbreviation:  J. Virol.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-11     Completed Date:  2013-08-12     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  7463-70     Citation Subset:  IM    
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MeSH Terms
Base Sequence
Bayes Theorem
Central America / epidemiology
Evolution, Molecular*
Genetic Variation*
HIV Infections / epidemiology*,  transmission,  virology*
HIV-1 / classification,  genetics*
Likelihood Functions
Models, Genetic
Molecular Epidemiology
Molecular Sequence Data
Sequence Alignment
Sequence Analysis, DNA
pol Gene Products, Human Immunodeficiency Virus / genetics
Reg. No./Substance:
0/pol Gene Products, Human Immunodeficiency Virus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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