| Is single-dose fosfomycin trometamol a good alternative for asymptomatic bacteriuria in the second trimesterof pregnancy? | |
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MedLine Citation:
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PMID: 16941068 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Untreated asymptomatic bacteriuria has been associated with acute pyelonephritis, which may have a role in many maternal and fetal complications. Acute pyelonephritis in pregnancy is related to anemia, septicemia, transient renal dysfunction, and pulmonary insufficiency. A randomized study was conducted to assess the clinical and microbiological efficacy of a single dose of fosfomycin trometamol for the treatment of asymptomatic bacteriuria in the second trimester of pregnancy compared with a 5-day regimen of cefuroxime axetyl. Forty-four women received fosfomycin trometamol and 40 women received cefuroxime axetyl. There were no statistically significant differences between both groups regarding the mean age and mean duration of pregnancy. Therapeutic success was achieved in 93.2% of the patients treated with fosfomycin trometamol vs 95% of those treated with cefuroxime axetyl. A single dose of fosfomycin trometamol is a safe and effective alternative in the treatment of asymptomatic urinary tract infections in the second trimester of pregnancy. |
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Authors:
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Omer Bayrak; Ersin Cimentepe; Ilknur Inegöl; Ali Fuat Atmaca; Candan Iltemir Duvan; Akif Koç; Nilgün Oztürk Turhan |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial Date: 2006-08-29 |
Journal Detail:
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Title: International urogynecology journal and pelvic floor dysfunction Volume: 18 ISSN: - ISO Abbreviation: Int Urogynecol J Pelvic Floor Dysfunct Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-04-04 Completed Date: 2007-06-19 Revised Date: 2011-08-18 |
Medline Journal Info:
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Nlm Unique ID: 9514583 Medline TA: Int Urogynecol J Pelvic Floor Dysfunct Country: England |
Other Details:
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Languages: eng Pagination: 525-9 Citation Subset: IM |
Affiliation:
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Department of Urology, Fatih University School of Medicine, Alpaslan Türkeş cad., 06510 Emek, Ankara, Turkey. omerbayrak69@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Anti-Bacterial Agents / administration & dosage* Bacteriuria / drug therapy* Cefuroxime / administration & dosage, analogs & derivatives Drug Administration Schedule Escherichia coli Infections / drug therapy Female Fosfomycin / administration & dosage* Humans Pregnancy Pregnancy Complications, Infectious / drug therapy* Pregnancy Trimester, Second* Safety Single-Blind Method Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 23155-02-4/Fosfomycin; 55268-75-2/Cefuroxime; 64544-07-6/cefuroxime axetil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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