Document Detail

A single-dose comparison of three slow-release theophylline oral preparations in healthy Thai volunteers.
MedLine Citation:
PMID:  8980795     Owner:  NLM     Status:  MEDLINE    
The study was done to compare the pharmacokinetic characteristics of three slow-release theophylline (SRT) preparations. Twelve healthy nonsmokers were randomly assigned a single dose of the following treatments at weekly intervals: Theo-Dur, Theo-24 or Xanthium orally, or aminophylline intravenously. Serially collected serum samples were analyzed for theophylline with use of fluorescence polarization immunoassay (FPIA). All three SRT preparations showed reliable absorption characteristics, but Theo-Dur had a shorter Tmax and MRT and a higher Ka. The pharmacokinetic characteristics of Theo-24 and Xanthium were similar except that Xanthium had lower bioavailability. Using single dose data for simulation of steady state pharmacokinetics, we found that a once-a-day dosage regimen with either Theo-24 or Xanthium would maintain serum levels within the therapeutic range for average non-smoking young adults whereas more frequent dosing intervals with Theo-Dur would be more appropriate. Our results argue against open substitution of SRT preparations without, close monitoring of the serum theophylline concentrations when a change is made.
S Kanthawatana; A Tontayapiwat; W Tonsuwannont; M Manorot
Related Documents :
16958785 - Effect of ofloxacin on theophylline pharmacokinetics at clinical dosage in dogs.
1977715 - Prognostic potential of serum ca 125 levels in danazol-treated patients with external e...
3053575 - Interaction between the fluoroquinolones and the bronchodilator theophylline.
1745845 - Long-term low-dose administration of erythromycin to patients with diffuse panbronchiol...
25309945 - Population-based pharmacokinetic modeling of vancomycin in children with renal insuffic...
25386405 - Effects of hypericum perforatum extract on igg titer, leukocytes subset and spleen inde...
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Asian Pacific journal of allergy and immunology / launched by the Allergy and Immunology Society of Thailand     Volume:  14     ISSN:  0125-877X     ISO Abbreviation:  Asian Pac. J. Allergy Immunol.     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1997-03-18     Completed Date:  1997-03-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8402034     Medline TA:  Asian Pac J Allergy Immunol     Country:  THAILAND    
Other Details:
Languages:  eng     Pagination:  13-8     Citation Subset:  IM    
Department of Pharmacology, Chiang Mai University Faculty of Medicine, Thailand.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Administration, Oral
Area Under Curve
Delayed-Action Preparations
Theophylline / administration & dosage,  pharmacokinetics*
Reg. No./Substance:
0/Delayed-Action Preparations; 58-55-9/Theophylline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Allergen skin test and total IgE in adults with rhinitis in Singapore.
Next Document:  The cellular immune status of HBsAg-positive carriers in Malaysia.