Document Detail

A single-compartment model cannot describe passive expiration in intubated, paralysed humans.
MedLine Citation:
PMID:  1855575     Owner:  NLM     Status:  MEDLINE    
The time-course of thoracic volume changes (respiratory inductive plethysmograph) during relaxed expiration was studied in 11 intubated, paralysed, mechanically ventilated subjects. The semilog volume-time curves show that expiration is governed by two apparently separate mechanisms: one causes emptying of most of the expired volume (approximately 80%) with a time constant of 0.50 +/- 0.22 s for a baseline tidal volume of 0.44 +/- 0.12 l (mean +/- SD) and 0.37 +/- 0.14 s when the tidal volume is reduced (VTP); the other contributes a relatively small amount to the expired volume over a significantly longer time, the time constant amounting to 3.27 +/- 1.54 s for baseline VT and 2.95 +/- 1.65 s for VTp. The first mechanism probably reflects the standard elastic and flow resistive properties of the respiratory system, while the second, slower compartment, is probably an expression of the viscoelastic properties of the pulmonary and chest wall tissues.
G L Chelucci; F Brunet; J Dall'Ava-Santucci; J F Dhainaut; D Paccaly; A Armaganidis; J Milic-Emili; A Lockhart
Related Documents :
12878615 - Quantal ventilatory variability during spontaneous breathing anaesthesia.
3942375 - Breathlessness and exercise in patients with cardiorespiratory disease.
7224355 - The effects of inspiratory muscle training on exercise performance in chronic airflow l...
16575025 - Expiratory threshold loading impairs cardiovascular function in health and chronic hear...
1854035 - Visceral losses of desflurane, isoflurane, and halothane in swine.
14672435 - Evaluation of serum concentrations of biochemical markers of bone metabolism and insuli...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The European respiratory journal     Volume:  4     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-08-23     Completed Date:  1991-08-23     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  458-64     Citation Subset:  IM; S    
Dipartimento di Fisiopatologia Clinica, Università di Firenze, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Coma / physiopathology
Intubation, Intratracheal*
Lung Volume Measurements
Models, Biological
Paralysis / physiopathology*
Pulmonary Ventilation / physiology
Respiration / physiology*
Respiration, Artificial*
Respiratory Mechanics / physiology
Suicide, Attempted

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Hyperreactivity and 45Ca movements in sensitized guinea-pig tracheal muscle.
Next Document:  Drug-induced lung disease: 1990 review.