Document Detail

A single blind comparison of dihydroergotoxine mesilate and clonidine for treatment of hypertensive emergencies.
MedLine Citation:
PMID:  3902677     Owner:  NLM     Status:  MEDLINE    
The effectiveness and safety of dihydroergotoxine mesylate (DHT) and clonidine (CLO) as acute antihypertensive treatments were studied in a single-blind randomized controlled study of 28 patients hospitalized after abrupt increases in mean blood pressure (MAP) to more than 150 mmHg, with concomitant symptoms related to hypertensive status (16 patients). Intravenous infusion of 1.5 mg DHT significantly reduced both systolic (SBP) and diastolic (DBP) blood pressure from 227 +/- 2/128 +/- 2 mmHg to 160 +/- 4/94 +/- 2 mmHg by 1 hour after the onset of infusion (p less than 0.01). In patients given CLO, BP values fell from 221 +/- 3/123 +/- 3 mmHg to 166 +/- 5/95 +/- 3 mmHg after 150 minutes. After that BP values did not change significantly up to 6 hours after both treatments. One hour after the onset of infusion, mean heart-rate (HR) had decreased by 15 beats/min in the DHT group and by 10 beats/min in the CLO-group. Twenty-one per cent of the patients given DHT and 78% of the patients given CLO complained of mild or moderate side-effects. The results of this study showed that DHT is an effective and well tolerated agent for the treatment of hypertensive emergencies and can be used safely even when continuous monitoring of blood pressure cannot be carried out.
E Guffanti; A Vaccarella; M Meregalli; G Fiorella; S M Chierichetti; C Mazzola
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  International journal of clinical pharmacology, therapy, and toxicology     Volume:  23     ISSN:  0174-4879     ISO Abbreviation:  Int J Clin Pharmacol Ther Toxicol     Publication Date:  1985 Sep 
Date Detail:
Created Date:  1985-12-13     Completed Date:  1985-12-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8003415     Medline TA:  Int J Clin Pharmacol Ther Toxicol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  506-9     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Clinical Trials as Topic
Clonidine / therapeutic use*
Dihydroergotoxine / therapeutic use*
Drug Tolerance
Heart Rate / drug effects
Hypertension / drug therapy*
Middle Aged
Random Allocation
Time Factors
Reg. No./Substance:
11032-41-0/Dihydroergotoxine; 4205-90-7/Clonidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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