Document Detail

A single bisphosphonate infusion is associated with improved functional capacity in elderly subjects with primary hyperparathyroidism.
MedLine Citation:
PMID:  14959954     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIMS: Neuromuscular symptoms are frequent features of primary hyperparathyroidism in elderly patients. Whether these symptoms are related to concomitant disorders or to hypercalcemia is of major importance in selecting patients who could benefit by parathyroidectomy. To address this hypothesis, we investigated the effects of transient normalization of calcemia on functional capacity by the administration of a single infusion of the bone resorption inhibitors pamidronate or clodronate. METHODS: Functional capacity was evaluated by the functional independence measure (FIM) in 25 patients aged 87.1+/-0.8 years (means+/-SEM) with primary hyperparathyroidism. Nine patients aged 88.4+/-1.1 with primary hyperparathyroidism, not receiving any bisphosphonate, were used as controls. RESULTS: By inhibiting bone resorption, bisphosphonate administration caused transient normalization of calcemia, associated with improved FIM, at a significantly higher level than in untreated patients (+16.1+/-6.0 vs +4.2+/-3.2%, p<0.05). CONCLUSIONS: If confirmed in a randomized prospective study, these results indicate that a single bisphosphonate infusion, with consecutive transient improvement of functional capacity in relation to plasma calcium normalization, could help in identifying elderly patients who would benefit by parathyroidectomy.
Patrick Ammann; Catherine Herter-Clavel; Alessandro Lubrano; René Rizzoli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Aging clinical and experimental research     Volume:  15     ISSN:  1594-0667     ISO Abbreviation:  Aging Clin Exp Res     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2004-02-12     Completed Date:  2004-08-31     Revised Date:  2006-03-08    
Medline Journal Info:
Nlm Unique ID:  101132995     Medline TA:  Aging Clin Exp Res     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  500-4     Citation Subset:  IM    
Bone Nutrition Unit, Department of Rehabilitation and Geriatrics, University Hospital, Thônex, Switzerland.
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MeSH Terms
Activities of Daily Living*
Aged, 80 and over
Antimetabolites / therapeutic use
Bone Resorption / prevention & control*
Bone and Bones / drug effects*
Calcium / blood
Clodronic Acid / therapeutic use*
Diphosphonates / therapeutic use*
Hypercalcemia / blood,  drug therapy*,  etiology
Hyperparathyroidism / complications*,  physiopathology
Retrospective Studies
Treatment Outcome
Reg. No./Substance:
0/Antimetabolites; 0/Diphosphonates; 10596-23-3/Clodronic Acid; 40391-99-9/pamidronate; 7440-70-2/Calcium

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