Document Detail

A single administration of methamphetamine to mice early in the light period decreases running wheel activity observed during the dark period.
MedLine Citation:
PMID:  22079320     Owner:  NLM     Status:  MEDLINE    
Repeated intermittent administration of amphetamines acutely increases appetitive and consummatory aspects of motivated behaviors as well as general activity and exploratory behavior, including voluntary running wheel activity. Subsequently, if the drug is withdrawn, the frequency of these behaviors decreases, which is thought to be indicative of dysphoric symptoms associated with amphetamine withdrawal. Such decreases may be observed after chronic treatment or even after single drug administrations. In the present study, the effect of acute methamphetamine (METH) on running wheel activity, horizontal locomotion, appetitive behavior (food access), and consummatory behavior (food and water intake) was investigated in mice. A multi-configuration behavior apparatus designed to monitor the five behaviors was developed, where combined measures were recorded simultaneously. In the first experiment, naïve male ICR mice showed gradually increasing running wheel activity over three consecutive days after exposure to a running wheel, while mice without a running wheel showed gradually decreasing horizontal locomotion, consistent with running wheel activity being a positively motivated form of natural motor activity. In experiment 2, increased horizontal locomotion and food access, and decreased food intake, were observed for the initial 3h after acute METH challenge. Subsequently, during the dark phase period decreased running wheel activity and horizontal locomotion were observed. The reductions in running wheel activity and horizontal locomotion may be indicative of reduced dopaminergic function, although it remains to be seen if these changes may be more pronounced after more prolonged METH treatments.
Nobue Kitanaka; Junichi Kitanaka; F Scott Hall; George R Uhl; Kaname Watabe; Hitoshi Kubo; Hitoshi Takahashi; Tomohiro Tatsuta; Yoshio Morita; Motohiko Takemura
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't     Date:  2011-10-26
Journal Detail:
Title:  Brain research     Volume:  1429     ISSN:  1872-6240     ISO Abbreviation:  Brain Res.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-11-28     Completed Date:  2012-03-20     Revised Date:  2014-08-18    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  155-63     Citation Subset:  IM    
Copyright Information:
Copyright © 2011. Published by Elsevier B.V.
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MeSH Terms
Behavior, Animal / drug effects*
Central Nervous System Stimulants / administration & dosage*
Circadian Rhythm / drug effects*
Methamphetamine / administration & dosage*
Mice, Inbred ICR
Motor Activity / drug effects*
Grant Support
Reg. No./Substance:
0/Central Nervous System Stimulants; 44RAL3456C/Methamphetamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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