Document Detail


A single 1-h bout of evening exercise increases basal FFA flux without affecting VLDL-triglyceride and VLDL-apolipoprotein B-100 kinetics in untrained lean men.
MedLine Citation:
PMID:  17264219     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Our group (Magkos F, Wright DC, Patterson BW, Mohammed BS, Mittendorfer B, Am J Physiol Endocrinol Metab 290: E355-E362, 2006) has recently demonstrated that a single, prolonged bout of moderate-intensity cycling (2 h at 60% of peak oxygen consumption) in the evening increases basal whole-body free fatty acid (FFA) flux and fat oxidation, decreases hepatic VLDL-apolipoprotein B-100 (apoB-100) secretion, and enhances removal efficiency of VLDL-triglyceride (TG) from the circulation the following day in untrained, healthy, lean men. In the present study, we investigated the effect of a single, shorter-duration bout of the same exercise (1 h cycling at 60% of peak oxygen consumption) on basal FFA, VLDL-TG, and VLDL-apoB-100 kinetics in seven untrained, healthy, lean men by using stable isotope-labeled tracer techniques. Basal FFA rate of appearance in plasma and plasma FFA concentration were approximately 55% greater (P < 0.05) the morning after exercise than rest, whereas resting metabolic rate and whole-body substrate oxidation rates were not different after rest and exercise. Exercise had no effect on plasma VLDL-TG and VLDL-apoB-100 concentrations, hepatic VLDL-TG and VLDL-apoB-100 secretion rates, and VLDL-TG and VLDL-apoB-100 plasma clearance rates (all P > 0.05). We conclude that in untrained, healthy, lean men 1) the exercise-induced changes in basal whole-body fat oxidation, VLDL-TG, and VLDL-apoB-100 metabolism during the late phase of recovery from exercise are related to the duration of the exercise bout; 2) single sessions of typical recreational activities appear to have little effect on basal, fasting plasma TG homeostasis; and 3) there is a dissociation between systemic FFA availability and VLDL-TG and VLDL-apoB-100 secretion by the liver.
Authors:
Faidon Magkos; Bruce W Patterson; B Selma Mohammed; Bettina Mittendorfer
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-01-30
Journal Detail:
Title:  American journal of physiology. Endocrinology and metabolism     Volume:  292     ISSN:  0193-1849     ISO Abbreviation:  Am. J. Physiol. Endocrinol. Metab.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-05     Completed Date:  2007-07-30     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  100901226     Medline TA:  Am J Physiol Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E1568-74     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Apolipoprotein B-100 / blood*
Circadian Rhythm*
Exercise / physiology*
Fatty Acids, Nonesterified / blood*
Humans
Insulin / blood
Kinetics
Lipoproteins, VLDL / blood*
Male
Osmolar Concentration
Oxygen Consumption
Thinness / blood*
Time Factors
Triglycerides / blood*
Grant Support
ID/Acronym/Agency:
AR-49869/AR/NIAMS NIH HHS; DK-56341/DK/NIDDK NIH HHS; P30 DK056341/DK/NIDDK NIH HHS; P30 DK056341-06/DK/NIDDK NIH HHS; P30 DK056341-07/DK/NIDDK NIH HHS; RR-00036/RR/NCRR NIH HHS; RR-00954/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Apolipoprotein B-100; 0/Fatty Acids, Nonesterified; 0/Insulin; 0/Lipoproteins, VLDL; 0/Triglycerides; 0/very low density lipoprotein triglyceride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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