| The simultaneous high expression of Vα24, IFN-γ and FoxP3 characterizes the liver of children with type I autoimmune hepatitis. | |
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MedLine Citation:
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PMID: 20884299 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The immunopathogenesis of type I autoimmune hepatitis (AIH-I) might involve the deregulation of different cellular processes. Here, we investigated the liver expression of selected cytokines and genes of regulatory cell populations in children both at diagnosis and during biochemical remission following immunosuppressive treatment (AIH-Ir). We found a higher Vα24, IFN-γ, FoxP3, IL-27p28, IL-12p40 and IL-21 expression at diagnosis as well as a positive correlation between IL-21 and transaminase levels. Interestingly, only IFN-γ and FoxP3 were decreased in AIH-Ir. An "AIH-I phenotype" (high Vα24, IFN-γ and FoxP3 expression at diagnosis) was observed in only 5 out of 22 AIH-Ir patients but not in controls. These results indicate a local deregulation of the innate and adaptive immune responses with an increased transcriptional activity of immunoregulatory cells at diagnosis. In addition, IL-21 is highlighted as a mediator of liver injury. AIH-Ir is characterized by a partial reversal of the deregulated response. |
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Authors:
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Nazarena E Ferreyra Solari; Cristina Galoppo; Miriam Cuarterolo; Javier Goñi; Luis Fernández-Salazar; Luis E Arranz; Jose A Garrote; Alejandra C Cherñavsky |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-29 |
Journal Detail:
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Title: Clinical immunology (Orlando, Fla.) Volume: 137 ISSN: 1521-7035 ISO Abbreviation: Clin. Immunol. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-08 Completed Date: 2010-11-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883537 Medline TA: Clin Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 396-405 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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División Inmunogenética, Hospital de Clínicas José de San Martín, Universidad de Buenos Aires, Buenos Aires, Argentina. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Biological Markers / metabolism Child Child, Preschool Female Forkhead Transcription Factors / genetics, metabolism* Gene Expression Regulation Hepatitis, Autoimmune / immunology, metabolism* Humans Interferon-gamma / genetics, metabolism* Interleukin-12 Subunit p40 / metabolism Interleukins / metabolism Liver / immunology, metabolism* Male Polymerase Chain Reaction RNA, Messenger / metabolism Receptors, Antigen, T-Cell / genetics, metabolism* Transaminases / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/FOXP3 protein, human; 0/Forkhead Transcription Factors; 0/IL27 protein, human; 0/Interleukin-12 Subunit p40; 0/Interleukins; 0/RNA, Messenger; 0/Receptors, Antigen, T-Cell; 0/Valpha24 protein, human; 0/interleukin-21; 82115-62-6/Interferon-gamma; EC 2.6.1.-/Transaminases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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