| A simulation study of irregular respiratory motion and its dosimetric impact on lung tumors. | |
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MedLine Citation:
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PMID: 21242627 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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This study is aimed at providing a dosimetric evaluation of the irregular motion of lung tumors due to variations in patients' respiration. Twenty-three lung cancer patients are retrospectively enrolled in this study. The motion of the patient clinical target volume is simulated and two types of irregularities are defined: characteristic and uncharacteristic motions. Characteristic irregularities are representative of random fluctuations in the observed target motion. Uncharacteristic irregular motion is classified as systematic errors in determination of the target motion during the planning session. Respiratory traces from measurement of patient abdominal motion are also used for the target motion simulations. Characteristic irregular motion was observed to cause minimal changes in target dosimetry with the largest effect of 2.5% ± 0.9% (1σ) reduction in the minimum target dose (D(min)) observed for targets that move 2 cm on average and exhibiting 50% amplitude variations within a session. However, uncharacteristic irregular motion introduced more drastic changes in the clinical target volume (CTV) dose; 4.1% ± 1.7% reduction for 1 cm motion and 9.6% ± 1.7% drop for 2 cm. In simulations with patients' abdominal motion, corresponding changes in target dosimetry were observed to be negligible (<0.1%). Only uncharacteristic irregular motion was identified as a clinically significant source of dosimetric uncertainty. |
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Authors:
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Y D Mutaf; C J Scicutella; D Michalski; K Fallon; E D Brandner; G Bednarz; M S Huq |
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Publication Detail:
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Type: Journal Article Date: 2011-01-17 |
Journal Detail:
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Title: Physics in medicine and biology Volume: 56 ISSN: 1361-6560 ISO Abbreviation: Phys Med Biol Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401220 Medline TA: Phys Med Biol Country: England |
Other Details:
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Languages: eng Pagination: 845-59 Citation Subset: IM |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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