Document Detail


A simplified two-component model of blood pressure fluctuation.
MedLine Citation:
PMID:  17012354     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We propose a simple moving-average (MA) model that uses the low-frequency (LF) component of the peroneal muscle sympathetic nerve spike rate (LF(spike rate)) and the high-frequency (HF) component of respiration (HF(Resp)) to describe the LF neurovascular fluctuations and the HF mechanical oscillations in systolic blood pressure (SBP), respectively. This method was validated by data from eight healthy subjects (23-47 yr old, 6 male, 2 female) during a graded tilt (15 degrees increments every 5 min to a 60 degrees angle). The LF component of SBP (LF(SBP)) had a strong baroreflex-mediated feedback correlation with LF(spike rate) (r = -0.69 +/- 0.05) and also a strong feedforward relation to LF(spike rate) [r = 0.58 +/- 0.03 with LF(SBP) delay (tau) = 5.625 +/- 0.15 s]. The HF components of spike rate (HF(spike rate)) and SBP (HF(SBP)) were not significantly correlated. Conversely, HF(Resp) and HF(SBP) were highly correlated (r = -0.79 +/- 0.04), whereas LF(Resp) and LF(SBP) were significantly less correlated (r = 0.45 +/- 0.08). The mean correlation coefficients between the measured and model-predicted LF(SBP) (r = 0.74 +/- 0.03) in the supine position did not change significantly during tilt. The mean correlation between the measured and model-predicted HF(SBP) was 0.89 +/- 0.02 in the supine position. R(2) values for the regression analysis of the model-predicted and measured LF and HF powers indicate that 78 and 91% of the variability in power can be explained by the linear relation of LF(spike rate) to LF(SBP) and HF(Resp) to HF(SBP). We report a simple two-component model using neural sympathetic and mechanical respiratory inputs that can explain the majority of blood pressure fluctuation at rest and during orthostatic stress in healthy subjects.
Authors:
Robert J Brychta; Richard Shiavi; David Robertson; Italo Biaggioni; André Diedrich
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2006-09-29
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  292     ISSN:  0363-6135     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-08     Completed Date:  2007-03-20     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H1193-203     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Baroreflex*
Blood Pressure / physiology*
Dizziness / physiopathology*
Female
Humans
Linear Models
Male
Middle Aged
Models, Cardiovascular*
Predictive Value of Tests
Reference Values
Respiratory Mechanics / physiology*
Supine Position
Sympathetic Nervous System / physiology*
Systole
Time Factors
Grant Support
ID/Acronym/Agency:
1P01 HL-56693/HL/NHLBI NIH HHS; P01 HL056693/HL/NHLBI NIH HHS; RR-00095/RR/NCRR NIH HHS
Comments/Corrections

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