Document Detail

A simplified screening protocol predicts pathological electroneurographic results in patients with suspected polyneuropathy.
MedLine Citation:
PMID:  20128669     Owner:  NLM     Status:  MEDLINE    
Electroneurographic testing is one of the standard instruments to detect polyneuropathy (PNP). The objective of this study was to develop a screening tool with optimized sensitivity and specificity, consisting of a short questionnaire and a short standardized neurological examination. One hundred one patients with a suspected PNP were prospectively selected from the neurological outpatient clinic. We used a short questionnaire and a short neurological examination derived from the Michigan Neuropathy Screening Instrument (MNSI). Based on electroneurographic results, patients were classified in three groups of different severity. The diagnostic power of the MNSI was optimized by constructing a score based on two combined discrimination functions. The optimized screening tool was able to detect patients suffering from PNP at a sensitivity of 88%. In particular, a severe form of PNP was recognized at a sensitivity of 97%. The specificity to detect healthy subjects was 74%. This new tool is a fast and easy to use instrument which can give a decision support for general practitioners for patients with a suspected PNP as to whether a subsequent electroneurographical examination (ENG) testing will show pathological results.
Oliver H?ffken; Christoph Maier; Helmut Richter; Martin Tegenthoff; Peter Schwenkreis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The International journal of neuroscience     Volume:  120     ISSN:  1563-5279     ISO Abbreviation:  Int. J. Neurosci.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-04     Completed Date:  2010-04-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0270707     Medline TA:  Int J Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  28-35     Citation Subset:  IM    
Department of Neurology, Ruhr-University Bochum, BG-Kliniken Bergmannsheil, Bochum, Germany.
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MeSH Terms
Analysis of Variance
Discriminant Analysis
Electric Stimulation / methods
Electromyography / methods*
Mass Screening / methods
Middle Aged
Neural Conduction / physiology
Neurologic Examination / methods*
Polyneuropathies / diagnosis*,  physiopathology
Prospective Studies
Reaction Time
Sensitivity and Specificity
Severity of Illness Index

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