| A simplified method using somatostatin to assess in vivo insulin resistance over a range of obesity. | |
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MedLine Citation:
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PMID: 488547 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twenty-one nondiabetic subjects, their weights ranging from 56 to 165 kg, received an infusion of glucose (420 mg/min), insulin (0.77 mU/kg/min), and somatostatin (500 microgram/h) for 150 min. A steady state level of plasma insulin and glucose was attained after 90 min. Endogenous insulin secretion determined by C-peptide measurement, and glucagon secretion remained suppressed throughout the period. With similar steady state levels of plasma insulin (SSPI) maintained in all subjects, the height of the steady state plasma glucose concentration (SSPG) was considered an index of total body sensitivity to insulin-mediated glucose uptake. A positive correlation between SSPG and the degree of obesity, as determined by the body mass index (BMI), was demonstrated (r = 0.70, P less than 0.001). No correlation was found between SSPI and BMI. The fasting plasma insulin concentration correlated with BMI (r = 0.82, P less than 0.0001) and SSPG (r = 0.80, P less than 0.0001). This method provides a simple safe measure of total body insulin resistance over a wide range of obesity and is independent of endogenous insulin secretion. |
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Authors:
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M Nagulesparan; P J Savage; R H Unger; P H Bennett |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Diabetes Volume: 28 ISSN: 0012-1797 ISO Abbreviation: Diabetes Publication Date: 1979 Nov |
Date Detail:
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Created Date: 1979-12-29 Completed Date: 1979-12-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372763 Medline TA: Diabetes Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 980-3 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Blood Glucose / analysis Fasting Female Glucose / diagnostic use Humans Insulin / blood Insulin Resistance* Male Obesity / physiopathology* Somatostatin / diagnostic use* |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 11061-68-0/Insulin; 50-99-7/Glucose; 51110-01-1/Somatostatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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