Document Detail

A simplified method to decrease operative blood loss in laparoscopic-assisted vaginal hysterectomy for the large uterus.
MedLine Citation:
PMID:  15559351     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVE. To evaluate the role of oxytocin in decreasing operative blood loss in laparoscopic-assisted vaginal hysterectomy (LAVH) for the large uterus (weight > or = 500 g). DESIGN: Prospective clinical study (Canadian Task Force classification II-2). SETTING: Tertiary care university hospital. PATIENTS: Eighty-eight women scheduled for a hysterectomy for large benign uterine tumors. INTERVENTION: Two ampules of oxytocin (10 u/mL/amp) were added to 1000 mL of saline solution running at the rate of 40 mU/min during the course of LAVH. MEASUREMENTS AND MAIN RESULTS: Blood loss and blood transfusion rate were significantly greater in the group without oxytocin infusion (group B) than in the group with oxytocin infusion (group A), with 485.7 +/- 321.6 mL versus 364.1 +/- 173.2 mL (p <.05) and 26.7% versus 6. 1% (p <.05), respectively. There was no significant difference in average age, body weight, and number of vaginal deliveries and cesarean sections between the two groups. There also was no significant difference in mean uterine weight, postoperative stay, and complications between the two groups. CONCLUSION: Oxytocin infusion can cause uterine contractions that decrease uterine perfusion. It is a safe and inexpensive method to help decrease operative blood loss during LAVH for the large uterus.
Chin-Jung Wang; Leung-To Yuen; Chih-Feng Yen; Chyi-Long Lee; Yung-Kuei Soong
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Journal of the American Association of Gynecologic Laparoscopists     Volume:  11     ISSN:  1074-3804     ISO Abbreviation:  J Am Assoc Gynecol Laparosc     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-11-22     Completed Date:  2004-12-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9417443     Medline TA:  J Am Assoc Gynecol Laparosc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  370-3     Citation Subset:  IM    
Division of Gynecologic Endoscopy, Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Linkou Medical Center, 5, Fu-Hsin Street, Kwei-Shan Tao-Yuan, Taiwan.
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MeSH Terms
Blood Loss, Surgical / prevention & control*
Hysterectomy, Vaginal / adverse effects*,  methods
Leiomyoma / surgery*
Middle Aged
Organ Size
Oxytocics / therapeutic use
Oxytocin / therapeutic use
Prospective Studies
Uterine Neoplasms / surgery*
Uterus / pathology*
Reg. No./Substance:
0/Oxytocics; 50-56-6/Oxytocin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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