| A simplified arteriovenous malformation model in sheep: feasibility study. | |
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MedLine Citation:
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PMID: 10369342 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: Recently, a swine model of a cerebral arteriovenous malformation (AVM) has been developed that closely resembles a human AVM of the brain. The creation of such a model requires sophisticated neurointerventional techniques. The purpose of this study was to develop a simple and cost-effective AVM animal model that does not require additional endovascular techniques. METHODS: A surgical anastomosis was created in seven sheep between the common carotid artery and the ipsilateral jugular vein, followed by ligation of the jugular vein above the anastomosis and of the proximal common carotid artery below the anastomosis. The anastomosis was created on the left side in four animals and on the right side in three. Cerebral angiography from the contralateral carotid artery was performed before and immediately after surgery to delineate the relevant cerebral vascular anatomy and to determine the direction of blood flow. RESULTS: An angiographic appearance simulating an AVM was found in all the animals. The ramus anastomoticus and arteria anastomotica functioned as the feeding vessels to the rete mirabile, which represented the nidus in our model, and to the jugular vein, which represented the draining vein from the malformation. Extensive collateral flow through the rete mirabile into the distal segment of the external carotid artery above the ligature was observed angiographically, with retrograde flow through the surgical anastomosis into the jugular vein. CONCLUSION: A simple surgically created experimental model for cerebral AVMs was developed in sheep without the need for additional complex endovascular catheter manipulations of intracranial branches. Such an animal model can substantially reduce the cost of research and training in the neurointerventional or radiosurgical management of AVMs. |
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Authors:
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Z Qian; S Climent; M Maynar; J Usón-Garallo; M A Lima-Rodrigues; C Calles; H Robertson; W R Castañeda-Zúñiga |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: AJNR. American journal of neuroradiology Volume: 20 ISSN: 0195-6108 ISO Abbreviation: AJNR Am J Neuroradiol Publication Date: 1999 May |
Date Detail:
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Created Date: 1999-07-27 Completed Date: 1999-07-27 Revised Date: 2008-02-14 |
Medline Journal Info:
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Nlm Unique ID: 8003708 Medline TA: AJNR Am J Neuroradiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 765-70 Citation Subset: IM |
Affiliation:
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Department of Radiology, LSU Medical Center at New Orleans, LA 70112, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anastomosis, Surgical Animals Carotid Artery, Common / surgery Cerebral Angiography Disease Models, Animal* Feasibility Studies Female Intracranial Arteriovenous Malformations* / radiography Jugular Veins / surgery Ligation Male Sheep* |
| Comments/Corrections | |
Comment In:
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AJNR Am J Neuroradiol. 2000 May;21(5):985-90
[PMID:
10815687
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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