Document Detail

A simple synthesis of 11,19-oxidosteroids.
MedLine Citation:
PMID:  7570715     Owner:  NLM     Status:  MEDLINE    
The photochemical hypoiodination of cortisol acetonide gave a mixture of 18-iodocortisol acetonide and of the 11 beta,19-oxidoderivative. The proportion of the two products was slightly modified by the reaction temperature. Deprotection of the acetonide group of the 11 beta,19-oxidoderivative gave 11 beta,19-oxido-17 alpha,21-dihydroxy-4-pregnen-3,20-dione which led to the formation of 11 beta,19-oxido-4-androsten-3,17-dione upon treatment with sodium bismutate.
A Boudi; A Zaparucha; H Galons; M Chiadmi; B Viossat; A Tomas; J Fiet
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Steroids     Volume:  60     ISSN:  0039-128X     ISO Abbreviation:  Steroids     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-10-24     Completed Date:  1995-10-24     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  0404536     Medline TA:  Steroids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  411-3     Citation Subset:  IM    
Laboratoire de biologie hormonale, Hôpital Saint Louis, Paris, France.
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MeSH Terms
Androstenedione / analogs & derivatives*,  chemical synthesis,  chemistry
Chromatography, Thin Layer
Hydrocortisone / analogs & derivatives*,  chemical synthesis,  chemistry
Iodine / chemistry*
Magnetic Resonance Spectroscopy
Models, Chemical
Molecular Structure
Oxidants, Photochemical / chemistry*
Reg. No./Substance:
0/11,19-oxido-17,21-dihydroxy-4-pregnen-3,20-dione; 0/11,19-oxido-4-androsten-3,17-dione; 0/Oxidants, Photochemical; 0/cortisol acetonide; 50-23-7/Hydrocortisone; 63-05-8/Androstenedione; 7553-56-2/Iodine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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