| A simple "streak length method" for quantifying and characterizing red blood cell velocity profiles and blood flow in rat skeletal muscle arterioles. | |
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MedLine Citation:
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PMID: 22284025 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objectives: 1) Develop a valid experimental method for quantifying blood flow in continuously branching skeletal muscle arterioles, and 2) derive an empirical relationship between velocity ratio (V(Max) /V(Mean) ) and arteriolar diameter. Methods: We evaluated arteriolar trees using intravital video microscopy of rat gluteus maximus muscle and developed a method to acquire single fluorescent-labelled red blood cell velocities across arteriolar lumens to create velocity profiles. These data were used to calculate blood flow for 37 vessel segments (diameters: 21-115 μm). Results: Mass balance at arteriolar bifurcations had 0.6 ± 3.2% error. Velocity ratios ranged from 1.35 to 1.98, were positively correlated with diameter (P < 0.0001), and V(RBC) profiles were blunted with decreasing diameter. Conclusions: We present a means for quantifying blood flow in continuously branching skeletal muscle arterioles. Further, we provide an equation for calculating velocity ratios based on arteriolar diameter, which may be used by others for blood flow calculations. |
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Authors:
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Baraa K Al-Khazraji; Nicole M Novielli; Daniel Goldman; Philip J Medeiros; Dwayne N Jackson |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-28 |
Journal Detail:
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Title: Microcirculation (New York, N.Y. : 1994) Volume: - ISSN: 1549-8719 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9434935 Medline TA: Microcirculation Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 John Wiley & Sons Ltd. |
Affiliation:
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Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada Biomedical Engineering Program, University of Western Ontario, London, Ontario, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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