Document Detail

A simple and rapid approach to hypokalemic paralysis.
MedLine Citation:
PMID:  14574658     Owner:  NLM     Status:  MEDLINE    
Hypokalemia with paralysis (HP) is a potentially reversible medical emergency. It is primarily the result of either hypokalemic periodic paralysis (HPP) caused by an enhanced shift of potassium (K(+)) into cells or non-HPP resulting from excessive K(+) loss. Failure to make a distinction between HPP and non-HPP could lead to improper management. The use of spot urine for K(+) excretion rate and evaluation of blood acid-base status could be clinically beneficial in the diagnosis and management. A very low rate of K(+) excretion coupled with the absence of a metabolic acid-base disorder suggests HPP, whereas a high rate of K(+) excretion accompanied by either metabolic alkalosis or metabolic acidosis favors non-HPP. The therapy of HPP requires only small doses of potassium chloride (KCl) to avoid rebound hyperkalemia. In contrast, higher doses of KCl should be administered to replete the large K(+) deficiency in non-HPP.
Shih-Hua Lin; Jainn-Shiun Chiu; Chin-Wang Hsu; Tom Chau
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The American journal of emergency medicine     Volume:  21     ISSN:  0735-6757     ISO Abbreviation:  Am J Emerg Med     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-10-23     Completed Date:  2003-12-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8309942     Medline TA:  Am J Emerg Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  487-91     Citation Subset:  IM    
Division of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, R.O.C.
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MeSH Terms
Acid-Base Equilibrium
Bartter Syndrome / complications,  diagnosis,  therapy
Diagnosis, Differential
Emergency Medical Services / methods
Hyperthyroidism / complications,  diagnosis,  therapy
Hypokalemic Periodic Paralysis / blood,  complications,  diagnosis*,  therapy*,  urine
Infusions, Intravenous
Potassium / urine
Potassium Chloride / administration & dosage
Sjogren's Syndrome / diagnosis,  therapy
Treatment Outcome
Reg. No./Substance:
7440-09-7/Potassium; 7447-40-7/Potassium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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