Document Detail

A simple presurgical necrotizing enterocolitis-mortality scoring system.
MedLine Citation:
PMID:  17122786     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the relationship between early laboratory parameters, disease severity, type of management (surgical or conservative) and outcome in necrotizing enterocolitis (NEC). STUDY DESIGN: Retrospective collection and analysis of data from infants treated in a single tertiary care center (1980 to 2002). Data were collected on disease severity (Bell stage), birth weight (BW), gestational age (GA) and pre-intervention laboratory parameters (leukocyte and platelet counts, hemoglobin, lactate, C-reactive protein). RESULTS: Data from 128 infants were sufficient for analysis. Factors significantly associated with survival were Bell stage (P<0.05), lactate (P<0.05), BW and GA (P<0.01, P<0.001, respectively). From receiver operating characteristics curves, the highest predictive value resulted from a score with 0 to 8 points combining BW, Bell stage, lactate and platelet count (P<0.001). At a cutoff level of 4.5 sensitivity and specificity for predicting survival were 0.71 and 0.72, respectively. CONCLUSION: Some single parameters were associated with poor outcome in NEC. Optimal risk stratification was achieved by combining several parameters in a score.
U Kessler; A Mungnirandr; M Nelle; A F Nimmo; Z Zachariou; S Berger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  26     ISSN:  0743-8346     ISO Abbreviation:  J Perinatol     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-23     Completed Date:  2007-03-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  764-8     Citation Subset:  IM    
Department of Surgical Pediatrics, Inselspital, University of Berne, Switzerland.
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MeSH Terms
Birth Weight*
Enterocolitis, Necrotizing / blood,  classification*,  mortality,  therapy
Gestational Age
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / classification,  mortality,  therapy
Lactic Acid / blood*
ROC Curve
Retrospective Studies
Sensitivity and Specificity
Severity of Illness Index
Survival Analysis
Reg. No./Substance:
50-21-5/Lactic Acid

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