Document Detail


A simple ordering of neocortical areas established by the compartmental organization of their striatal projections.
MedLine Citation:
PMID:  1696719     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The compartmental organization of corticostriatal projections from the fronto-orbito-insular cortex was studied in the cat. Cortical areas in this field were found to have a highly organized projection to the striatum, selectively innervating striosomes dorsally and predominantly avoiding them ventrally within their striatal fields of termination. These observations have two important implications for striatal processing. First, some cortical areas preferentially terminate in different compartments in different parts of the striatum. Therefore, the sources of input to striosomes and matrix are not categorical but switch according to the striatal region considered. Second, three properties of the bicompartmental termination pattern--one-dimensionality, common polarization, and multiple positions at which the pattern switched from "fills" to "avoids"--allowed us to order the corticostriatal projections with respect to one another. This ordering of the striatal projections of cortical areas implies an ordering of the cortical areas themselves, one that is independent of transcortical connections. For the corticostriatal projections described in this report, the ordering is [parietal, dorsomedial prefrontal, ventrolateral prefrontal, insular, rostral temporal] cortex. Our analysis suggests that a major function of striatal compartmentalization is to segregate and then bring together inputs from cortical areas at different positions in this ordering. The ordering may also serve as a simple format for specifying corticostriatal connections in development.
Authors:
C W Ragsdale; A M Graybiel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  87     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1990-09-20     Completed Date:  1990-09-20     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  6196-9     Citation Subset:  IM    
Affiliation:
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139.
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MeSH Terms
Descriptor/Qualifier:
Animals
Autoradiography
Axonal Transport
Cats
Cerebral Cortex / anatomy & histology,  cytology,  physiology*
Corpus Striatum / anatomy & histology,  cytology,  physiology*
Leucine / metabolism
Methionine / metabolism
Proline / metabolism
Tritium
Grant Support
ID/Acronym/Agency:
EY02866-10A1/EY/NEI NIH HHS; NS25529-02/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
10028-17-8/Tritium; 147-85-3/Proline; 61-90-5/Leucine; 63-68-3/Methionine
Comments/Corrections

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