Document Detail

A simple method to clamp end-tidal carbon dioxide during rest and exercise.
MedLine Citation:
PMID:  22736248     Owner:  NLM     Status:  Publisher    
Carbon dioxide regulates ventilation and cerebral blood flow during exercise. There are significant limitations in breathing systems designed to control end-tidal gas concentrations when used during high-intensity exercise. We designed a simple, inexpensive breathing system which controls end-tidal carbon dioxide ([Formula: see text]) during exercise from rest to peak work capacity (W (max)). The system is operated by an investigator who, in response to breath-by-breath [Formula: see text], titrates flow of a 10 % CO(2), 21 % O(2) mixture into an open-ended 5-L inspiratory reservoir. To demonstrate system efficacy, nine fit male subjects performed two maximal, incremental exercise tests (25 W min(-1) ramp) on a cycle ergometer: a poikilocapnic control trial in which [Formula: see text] varied with work intensity, and an experimental trial, in which we planned to clamp [Formula: see text] at 50 mmHg. With our breathing system, we maintained [Formula: see text] at 51 ± 2 mmHg throughout exercise (rest, 50 ± 2; W (max), 52 ± 5 mmHg; mean ± SD) despite large changes in ventilation (range 27-65 at rest, 134-185 L min(-1) BTPS at W (max)) and carbon dioxide production (range 0.3-0.7 at rest, 4.5-5.5 L min(-1) at W (max)). This simple, inexpensive system achieves [Formula: see text] control at rest and throughout exercise.
J Tod Olin; Andrew C Dimmen; Andrew W Subudhi; Robert C Roach
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-27
Journal Detail:
Title:  European journal of applied physiology     Volume:  -     ISSN:  1439-6327     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Altitude Research Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA,
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