| A simple method to clamp end-tidal carbon dioxide during rest and exercise. | |
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MedLine Citation:
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PMID: 22736248 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Carbon dioxide regulates ventilation and cerebral blood flow during exercise. There are significant limitations in breathing systems designed to control end-tidal gas concentrations when used during high-intensity exercise. We designed a simple, inexpensive breathing system which controls end-tidal carbon dioxide ([Formula: see text]) during exercise from rest to peak work capacity (W (max)). The system is operated by an investigator who, in response to breath-by-breath [Formula: see text], titrates flow of a 10 % CO(2), 21 % O(2) mixture into an open-ended 5-L inspiratory reservoir. To demonstrate system efficacy, nine fit male subjects performed two maximal, incremental exercise tests (25 W min(-1) ramp) on a cycle ergometer: a poikilocapnic control trial in which [Formula: see text] varied with work intensity, and an experimental trial, in which we planned to clamp [Formula: see text] at 50 mmHg. With our breathing system, we maintained [Formula: see text] at 51 ± 2 mmHg throughout exercise (rest, 50 ± 2; W (max), 52 ± 5 mmHg; mean ± SD) despite large changes in ventilation (range 27-65 at rest, 134-185 L min(-1) BTPS at W (max)) and carbon dioxide production (range 0.3-0.7 at rest, 4.5-5.5 L min(-1) at W (max)). This simple, inexpensive system achieves [Formula: see text] control at rest and throughout exercise. |
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Authors:
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J Tod Olin; Andrew C Dimmen; Andrew W Subudhi; Robert C Roach |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-6-27 |
Journal Detail:
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Title: European journal of applied physiology Volume: - ISSN: 1439-6327 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-6-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100954790 Medline TA: Eur J Appl Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Altitude Research Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA, olint@njhealth.org. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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