Document Detail


A simple method of supplementation of omega-3 polyunsaturated fatty acids: use of fortified yogurt in healthy volunteers.
MedLine Citation:
PMID:  21139129     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: A relative dietary ω-3 fatty acid deficiency exists in Western diets, and this deficiency may be associated with some chronic diseases. The aim of the present study was to supplement yogurt with docosahexaenoic acid and assess whether this fatty acid could be incorporated into plasma lipids.
METHODS: We developed a stable emulsion of docosahexaenoic acid that was incorporated into yogurt. Twelve healthy volunteers agreed to consume 1 serving daily that contained 600 mg of docosahexaenoic acid.
RESULTS: After 3 weeks of supplementation, plasma phospholipid docosahexaenoic acid content increased significantly, by 32%, in parallel with a 16% rise in total ω-3 fatty acids. This result was associated with a significant 7% decline in phospholipid arachidonic acid.
CONCLUSIONS: Fortification of ordinary foods with docosahexaenoic acid is a potentially attractive method of increasing ω-3 fatty acid content of plasma lipids, and might even lower arachidonic acid concentrations.
Authors:
Karen C McCowen; Pei Ra Ling; Eric Decker; D Djordjevic; R F Roberts; J N Coupland; Bruce R Bistrian
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition     Volume:  25     ISSN:  1941-2452     ISO Abbreviation:  Nutr Clin Pract     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-08     Completed Date:  2011-05-24     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  8606733     Medline TA:  Nutr Clin Pract     Country:  United States    
Other Details:
Languages:  eng     Pagination:  641-5     Citation Subset:  IM; N    
Affiliation:
Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. kmccowen@bidmc.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Arachidonic Acid / blood*
Dietary Fats / administration & dosage*
Dietary Supplements
Docosahexaenoic Acids / administration & dosage,  blood,  pharmacology*
Emulsions
Fatty Acids, Omega-3 / blood
Food, Fortified*
Humans
Phospholipids / blood,  chemistry*
Yogurt*
Grant Support
ID/Acronym/Agency:
P30 DK040561-15/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/Emulsions; 0/Fatty Acids, Omega-3; 0/Phospholipids; 25167-62-8/Docosahexaenoic Acids; 506-32-1/Arachidonic Acid
Comments/Corrections

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