| A simple method of supplementation of omega-3 polyunsaturated fatty acids: use of fortified yogurt in healthy volunteers. | |
| | |
MedLine Citation:
|
PMID: 21139129 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: A relative dietary ω-3 fatty acid deficiency exists in Western diets, and this deficiency may be associated with some chronic diseases. The aim of the present study was to supplement yogurt with docosahexaenoic acid and assess whether this fatty acid could be incorporated into plasma lipids. METHODS: We developed a stable emulsion of docosahexaenoic acid that was incorporated into yogurt. Twelve healthy volunteers agreed to consume 1 serving daily that contained 600 mg of docosahexaenoic acid. RESULTS: After 3 weeks of supplementation, plasma phospholipid docosahexaenoic acid content increased significantly, by 32%, in parallel with a 16% rise in total ω-3 fatty acids. This result was associated with a significant 7% decline in phospholipid arachidonic acid. CONCLUSIONS: Fortification of ordinary foods with docosahexaenoic acid is a potentially attractive method of increasing ω-3 fatty acid content of plasma lipids, and might even lower arachidonic acid concentrations. |
| | |
Authors:
|
Karen C McCowen; Pei Ra Ling; Eric Decker; D Djordjevic; R F Roberts; J N Coupland; Bruce R Bistrian |
Related Documents
:
|
3964289 - Peroxidized lipids isolated by hplc from atherosclerotic aorta. 17094489 - Antioxidant and apoptosis-inducing activities of ellagic acid. 10604869 - Covalent modifications to 2'-deoxyguanosine by 4-oxo-2-nonenal, a novel product of lipi... 17201639 - Antioxidant capacity of crude extracts from clones of banana and plane species. 23017309 - Effects of omega-3 fatty acids supplementation on serum adiponectin levels and some met... 7622459 - Chlorination of tyrosyl residues in peptides by myeloperoxidase and human neutrophils. 6667719 - Increased intestinal absorption of oleic acid with aging in the rat. 1147909 - The binding of l-tryptophan to serum albumins in the presence of non-esterified fatty a... 18962959 - A desk-computer program for calculation of the parameters of acid-base titration curves... |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
|
Title: Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition Volume: 25 ISSN: 1941-2452 ISO Abbreviation: Nutr Clin Pract Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-12-08 Completed Date: 2011-05-24 Revised Date: 2013-05-27 |
Medline Journal Info:
|
Nlm Unique ID: 8606733 Medline TA: Nutr Clin Pract Country: United States |
Other Details:
|
Languages: eng Pagination: 641-5 Citation Subset: IM; N |
Affiliation:
|
Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. kmccowen@bidmc.harvard.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Arachidonic Acid
/
blood* Dietary Fats / administration & dosage* Dietary Supplements Docosahexaenoic Acids / administration & dosage, blood, pharmacology* Emulsions Fatty Acids, Omega-3 / blood Food, Fortified* Humans Phospholipids / blood, chemistry* Yogurt* |
| Grant Support | |
ID/Acronym/Agency:
|
P30 DK040561-15/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Dietary Fats; 0/Emulsions; 0/Fatty Acids, Omega-3; 0/Phospholipids; 25167-62-8/Docosahexaenoic Acids; 506-32-1/Arachidonic Acid |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Diet and inflammation.
Next Document: Clinical relevancy of the levothyroxine-continuous enteral nutrition interaction.