Document Detail


A simple method for preparing radioactive capsules in colon transit study.
MedLine Citation:
PMID:  10952498     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Colon transit study is currently performed by delivering technetium-99m or indium-111 labelled activated charcoal to the colon in a methacrylate-coated capsule (coated capsule). However, the coating procedure is complicated and methacrylate has not been approved by the Food and Drug Administration. Therefore, a simpler method is needed for the clinical routine use of colon transit study. In this study, we used a commercial empty enteric capsule and a coated capsule for the measurement of colon transit time. We compared the in vitro stability and in vivo scintigraphy of 99mTc-labelled activated charcoal in the coated capsule and the enteric capsule to evaluate the possibility of clinical usage of the enteric capsule for colon transit time study. Activated charcoal powder was mixed with 49mTc-diethylene triamine pentaacetic acid (DTPA) and vaporized to dryness. The dry 99mTc-DTPA activated charcoal was loaded into the coated capsule and the enteric capsule. In vitro stability study was performed by immersing these capsules in a colourless buffer of variable pH which mimicked the conditions in the stomach and the small bowel. Capsule disruption was determined. Colon transit scintigraphy with 99mTc-DTPA charcoal was performed in five normal volunteers using these two capsules. The in vitro stability of these two types of capsule was similar and the colon transit scintigraphy findings were almost identical. Most capsules dissolved in the ascending colon and very few in the terminal ileum. It is concluded that enteric capsule is a suitable alternative to coated capsule for measurement of colon transit.
Authors:
S J Wang; S C Tsai; W Y Lin; G H Chen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of nuclear medicine     Volume:  27     ISSN:  0340-6997     ISO Abbreviation:  Eur J Nucl Med     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2001-01-08     Completed Date:  2001-01-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7606882     Medline TA:  Eur J Nucl Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  857-60     Citation Subset:  IM    
Affiliation:
Department of Nuclear Medicine, Taichung Veterans General Hospital, Taiwan. sjwang@vghtc.vghtc.gov.tw
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MeSH Terms
Descriptor/Qualifier:
Capsules
Charcoal / diagnostic use*
Colon / physiology,  radionuclide imaging*
Delayed-Action Preparations
Gastrointestinal Transit*
Humans
Isotope Labeling
Methacrylates
Radiopharmaceuticals / diagnostic use*
Sodium Pertechnetate Tc 99m / diagnostic use*
Technetium Tc 99m Pentetate / diagnostic use*
Time Factors
Chemical
Reg. No./Substance:
0/Capsules; 0/Delayed-Action Preparations; 0/Methacrylates; 0/Radiopharmaceuticals; 16291-96-6/Charcoal; 23288-60-0/Sodium Pertechnetate Tc 99m; 65454-61-7/Technetium Tc 99m Pentetate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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