Document Detail


A simple integrated method for drug and derived metabolite kinetics. An application of the statistical moment theory.
MedLine Citation:
PMID:  6183086     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A simple integrated method for the calculation of elimination rate constants of a drug and its derived metabolite has been developed. This method is based on the statistical moment theory and requires only simple calculations of the area under the curve and area under the moment curve of the parent drug and its derived metabolite. The application to a drug following a one-compartmental model is theoretically well justified and this method may also be applicable to drugs following higher kinetic models under certain conditions. The application of this method to several experimental cases is also presented.
Authors:
K K Chan
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Drug metabolism and disposition: the biological fate of chemicals     Volume:  10     ISSN:  0090-9556     ISO Abbreviation:  Drug Metab. Dispos.     Publication Date:    1982 Sep-Oct
Date Detail:
Created Date:  1983-01-07     Completed Date:  1983-01-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9421550     Medline TA:  Drug Metab Dispos     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  474-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acecainide / metabolism
Animals
Biotransformation
Doxorubicin / metabolism
Kinetics
Models, Biological
Pharmaceutical Preparations / metabolism*
Procainamide / metabolism
Rabbits
Statistics as Topic
Warfarin / blood
Grant Support
ID/Acronym/Agency:
CA 14089-07/CA/NCI NIH HHS; CA 31693-01/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Pharmaceutical Preparations; 23214-92-8/Doxorubicin; 32795-44-1/Acecainide; 51-06-9/Procainamide; 81-81-2/Warfarin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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