Document Detail


A simple instrument for biochemical studies of the living human brain.
MedLine Citation:
PMID:  3491275     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A simple, relatively inexpensive radiation detection system was developed for measurement of positron-emitting receptor-binding drugs in the human brain. This high-efficiency coincidence counting system requires that only a few hundred microcuries of labeled drug be administered to the subject, thereby allowing for multiple studies without an excessive radiation dose. Measurement of the binding of [11C]-carfentanil, a high-affinity synthetic opiate, to opiate receptors in the presence and in the absence of a competitive opiate antagonist exemplifies the use of this system for estimating different degrees of receptor binding of drugs in the human brain. The instrument has also been used for measurement of the transport into the brain of other positron-emitting radiotracers, such as large neutral amino acids.
Authors:
A N Bice; H N Wagner; M C Lee; J J Frost
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Medical instrumentation     Volume:  20     ISSN:  0090-6689     ISO Abbreviation:  Med Instrum     Publication Date:    1986 Sep-Oct
Date Detail:
Created Date:  1987-01-06     Completed Date:  1987-01-06     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0361136     Medline TA:  Med Instrum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  244-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Binding, Competitive
Biochemistry / instrumentation*
Brain / metabolism,  radionuclide imaging*
Brain Chemistry*
Carbon Radioisotopes / administration & dosage,  diagnostic use
Child
Costs and Cost Analysis
Fentanyl / administration & dosage,  analogs & derivatives,  metabolism
Humans
Naloxone / administration & dosage,  metabolism
Receptors, Drug / metabolism
Tomography, Emission-Computed* / economics
Grant Support
ID/Acronym/Agency:
NS15080/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Carbon Radioisotopes; 0/Receptors, Drug; 437-38-7/Fentanyl; 465-65-6/Naloxone; 59708-52-0/carfentanil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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