Document Detail

A simple index to assess disease activity in rheumatoid arthritis.
MedLine Citation:
PMID:  8478879     Owner:  NLM     Status:  MEDLINE    
Changes in clinical and laboratory measures of disease activity were studied prospectively in 12 European centers. Altogether 282 rheumatoid patients were evaluated during 6 months of therapy with slow-acting drugs. Patients' global assessment was taken to indicate overall response. The number of swollen joints and number of tender joints correlated highly with this. The erythrocyte sedimentation rate (ESR) correlated less well but was more uniform across centers. Grip strength, C-reactive protein and hemoglobin performed poorly between centers. There were cultural and linguistic difficulties using the Health Assessment Questionnaire in a European setting. Physician's global assessments were similar to the patient's global assessments and provided redundant information. The best measures are: the number of swollen joints, the number of tender joints, the ESR, and the patient's global assessment. It may also help to measure articular pain.
D L Scott
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  20     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-05-27     Completed Date:  1993-05-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  582-4     Citation Subset:  IM    
Department of Rheumatology, St. Bartholomew's Hospital Medical College, London, UK.
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MeSH Terms
Arthritis, Rheumatoid* / epidemiology,  physiopathology,  therapy
C-Reactive Protein / analysis
Europe / epidemiology
Hemoglobins / analysis
Joints / pathology,  physiopathology
Multicenter Studies as Topic
Muscles / pathology,  physiopathology
Outcome Assessment (Health Care)*
Prospective Studies
Severity of Illness Index*
Treatment Outcome
Reg. No./Substance:
0/Hemoglobins; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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