Document Detail


A simple and fast experimental model of myocardial infarction in the mouse.
MedLine Citation:
PMID:  17041683     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this report, we describe a simple and fast method for creating a murine myocardial infarction model and providing a useful and convenient tool for the research in ischemic heart disease. We established acute myocardial infarction in the Kunming-strain mouse within 2 minutes by ligating the left anterior descending coronary artery. The model was evaluated by observing the changes in histology and in the serum levels of aspartate aminotransferase and lactate dehydrogenase. Obvious myocardial necrosis was found in the 24-hr experimental (ligation) group. The average size of the infarction was 44.3% +/- 2.9% of the left ventricle. Serum levels of aspartate aminotransferase and lactate dehydrogenase reached their peak in the 24-hr experimental group and were normal in the 72-hr experimental group. We set forth a simple and quick method for producing acute myocardial infarction experimentally in the mouse. The model can be reproduced in a stable manner, under experimental conditions that are easy to duplicate.
Authors:
Jinfeng Wang; Huaben Bo; Xiangying Meng; Yin Wu; Yongli Bao; Yuxin Li
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital     Volume:  33     ISSN:  0730-2347     ISO Abbreviation:  Tex Heart Inst J     Publication Date:  2006  
Date Detail:
Created Date:  2006-10-16     Completed Date:  2006-11-07     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  8214622     Medline TA:  Tex Heart Inst J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  290-3     Citation Subset:  IM    
Affiliation:
Institute of Genetics and Cytology, Northeast Normal University, Changchun 130024, People's Republic of China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Aspartate Aminotransferases / blood
Disease Models, Animal*
Female
L-Lactate Dehydrogenase / blood
Male
Mice
Mice, Inbred Strains
Myocardial Infarction* / blood,  pathology
Myocardium / cytology,  pathology
Necrosis
Chemical
Reg. No./Substance:
EC 1.1.1.27/L-Lactate Dehydrogenase; EC 2.6.1.1/Aspartate Aminotransferases
Comments/Corrections

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