Document Detail

A simple estimate of glomerular filtration rate in full-term infants during the first year of life.
MedLine Citation:
PMID:  6726515     Owner:  NLM     Status:  MEDLINE    
An estimate of glomerular filtration rate has been derived for children from body length (L, in centimeters) and plasma creatinine (Pcr, in milligrams per deciliter): GFR = 0.55 L/Pcr. The near universality of this estimate in children led us to seek a similar formula for estimating GFR in full-term infants during the first year of life. We measured Pcr in 137 healthy infants and performed creatinine clearance (Ccr) studies in 63 of them aged greater than or equal to 5 days. Beyond the first week, Pcr averaged 0.39 +/- 0.01 (0.10 SD) mg/dl. The estimate of GFR from 0.55 L/Pcr overestimated Ccr by 24% (P less than 0.001). Based on the calculation of a new constant from Ccr X Pcr/L, GFR was more accurately estimated from 0.45 L/Pcr (mean difference of Ccr - 0.45 L/Pcr = -0.4 +/- 3.7 (SE) ml/min X 1.73 m2) in full-term infants between 1 and 52 weeks of age. Because the constant 0.45 and Pcr do not change significantly during this period, GFR can be approximated at the bedside from body length of the healthy full-term infant (GFR = 0.45 L/0.39 = 1.1 L).
G J Schwartz; L G Feld; D J Langford
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  104     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1984 Jun 
Date Detail:
Created Date:  1984-07-09     Completed Date:  1984-07-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  849-54     Citation Subset:  AIM; IM    
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MeSH Terms
Age Factors
Body Height*
Body Weight
Creatinine / blood,  urine*
Glomerular Filtration Rate*
Grant Support
Reg. No./Substance:

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