| A simple and efficient route for preparing 2,3,5,6-tetraaminopyridine hydrochloride salt. | |
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MedLine Citation:
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PMID: 19471189 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A simple and efficient route for preparing 2,3,5,6-tetraaminopyridine hydrochloride salt (TAP x 3HCl x H(2)O) was introduced in this paper. The title compound was synthesized, as usual, in two steps (nitration and hydrogenation) with a total yield of 90%. The use of an oleum and fuming nitric acid mixture in the nitration step improved the yield and purity of the intermediate product. A highly efficient hydrogenation using a H(2)/Pd/C/C(2)H(5)OH system was developed. The products were characterized by TG, IR, (1)H-NMR, (13)C-NMR, HPLC and elemental analysis. |
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Authors:
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Yanhong Wang; Zhen Hu; Xiangli Meng; Jiehui Jing; Yuanjun Song; Chunhua Zhang; Yudong Huang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-04-27 |
Journal Detail:
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Title: Molecules (Basel, Switzerland) Volume: 14 ISSN: 1420-3049 ISO Abbreviation: Molecules Publication Date: 2009 |
Date Detail:
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Created Date: 2009-05-27 Completed Date: 2009-07-22 Revised Date: 2009-10-27 |
Medline Journal Info:
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Nlm Unique ID: 100964009 Medline TA: Molecules Country: Switzerland |
Other Details:
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Languages: eng Pagination: 1652-9 Citation Subset: IM |
Affiliation:
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Department of Applied Chemistry, Faculty of Science, Harbin Institute of Technology, Harbin, PR China. yanhongwang0213@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aminopyridines
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chemical synthesis*,
chemistry Hydrogenation Molecular Structure Nitric Acid / chemistry Salts / chemical synthesis*, chemistry |
| Chemical | |
Reg. No./Substance:
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0/Aminopyridines; 0/Salts; 7697-37-2/Nitric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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