Document Detail

A simple and effective strategy for labeling cysteine sulfenic acid in proteins by utilization of β-ketoesters as cleavable probes.
MedLine Citation:
PMID:  22430672     Owner:  NLM     Status:  MEDLINE    
β-ketoesters are robust probes for labeling sulfenic acid (-SOH) proteins allowing quantitative cleavage of the tag for improved analysis of the labeled peptides by MS.
Jiang Qian; Revati Wani; Chananat Klomsiri; Leslie B Poole; Allen W Tsang; Cristina M Furdui
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-03-20
Journal Detail:
Title:  Chemical communications (Cambridge, England)     Volume:  48     ISSN:  1364-548X     ISO Abbreviation:  Chem. Commun. (Camb.)     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-29     Completed Date:  2012-07-23     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  9610838     Medline TA:  Chem Commun (Camb)     Country:  England    
Other Details:
Languages:  eng     Pagination:  4091-3     Citation Subset:  IM    
Copyright Information:
This journal is © The Royal Society of Chemistry 2012
Department of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157, USA.
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MeSH Terms
Cell Survival
Cysteine / analogs & derivatives*,  analysis
Esters / chemistry
Ketones / chemistry
Models, Molecular
NIH 3T3 Cells
Proteins / chemistry*
Spectrometry, Mass, Electrospray Ionization*
Staining and Labeling
Sulfenic Acids / analysis*
Grant Support
R01 CA136810/CA/NCI NIH HHS; R01 CA136810/CA/NCI NIH HHS; R33 CA126659/CA/NCI NIH HHS; R33 CA126659/CA/NCI NIH HHS; R33 CA126659Z/CA/NCI NIH HHS
Reg. No./Substance:
0/Esters; 0/Ketones; 0/Proteins; 0/Sulfenic Acids; 52-90-4/Cysteine; FB8KIA847T/cysteinesulfenic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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