Document Detail

A simple approach to screening for microalbuminuria in a type 1 (insulin-dependent) diabetic population.
MedLine Citation:
PMID:  1958047     Owner:  NLM     Status:  MEDLINE    
The reproducibility of albumin concentration in first-morning samples of urine was assessed in 334 insulin-dependent diabetic patients aged 18-60 years. The albumin excretion rate was determined immunoturbidimetrically in three sterile, Albustix-negative, first-morning urine samples submitted over a week. An abnormally high mean value, greater than or equal to 2.5 mg albumin per mmol creatinine (Ua/Uc), was found in 33 patients (9.9%). These patients were older (mean 42 vs 34 years, P less than 0.01), had longer disease duration (18 vs 14 years, P less than 0.01) and higher HbA1c values (6.8 vs 6.3%, P less than 0.05) than those without microalbuminuria. Although triplicate samples were collected within 7 days, Ua/Uc showed considerable intraindividual variation, with a mean coefficient of variation of 49%. Despite this it was found that Ua/Uc values greater than 1 mg/mmol on the first specimen had a sensitivity of 97% and a specificity of 82% for detecting those with a three-sample mean value greater than 2.5 mg/mmol. Thus virtually all those with microalbuminuria (32/33) had a single first-morning result greater than 1 mg/mmol, and in those with a lower ratio microalbuminuria was excluded with more than 99% certainty.
K C McHardy; M E Gann; I S Ross; D W Pearson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of clinical biochemistry     Volume:  28 ( Pt 5)     ISSN:  0004-5632     ISO Abbreviation:  Ann. Clin. Biochem.     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1991-12-30     Completed Date:  1991-12-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0324055     Medline TA:  Ann Clin Biochem     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  450-5     Citation Subset:  IM    
Department of Medicine & Therapeutics, Aberdeen, UK.
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MeSH Terms
Albuminuria / diagnosis*
Creatinine / urine
Diabetes Mellitus, Type 1 / urine*
Diabetic Nephropathies / diagnosis
Middle Aged
Reproducibility of Results
Sensitivity and Specificity
Reg. No./Substance:

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