Document Detail


A simple approach to screening for microalbuminuria in a type 1 (insulin-dependent) diabetic population.
MedLine Citation:
PMID:  1958047     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The reproducibility of albumin concentration in first-morning samples of urine was assessed in 334 insulin-dependent diabetic patients aged 18-60 years. The albumin excretion rate was determined immunoturbidimetrically in three sterile, Albustix-negative, first-morning urine samples submitted over a week. An abnormally high mean value, greater than or equal to 2.5 mg albumin per mmol creatinine (Ua/Uc), was found in 33 patients (9.9%). These patients were older (mean 42 vs 34 years, P less than 0.01), had longer disease duration (18 vs 14 years, P less than 0.01) and higher HbA1c values (6.8 vs 6.3%, P less than 0.05) than those without microalbuminuria. Although triplicate samples were collected within 7 days, Ua/Uc showed considerable intraindividual variation, with a mean coefficient of variation of 49%. Despite this it was found that Ua/Uc values greater than 1 mg/mmol on the first specimen had a sensitivity of 97% and a specificity of 82% for detecting those with a three-sample mean value greater than 2.5 mg/mmol. Thus virtually all those with microalbuminuria (32/33) had a single first-morning result greater than 1 mg/mmol, and in those with a lower ratio microalbuminuria was excluded with more than 99% certainty.
Authors:
K C McHardy; M E Gann; I S Ross; D W Pearson
Related Documents :
9334907 - 24-hour ambulatory blood pressure and renal disease in young subjects with type i diabe...
9407457 - Urinary excretion of tgf-beta 1, pdgf-bb and fibronectin in insulin-dependent diabetes ...
2527677 - Comparison of methods for determination of microalbuminuria in diabetic patients.
14640237 - The effects of dual blockade of the renin-angiotensin system on urinary protein and tra...
2869997 - Comparison of glucose counterregulation during short-term and prolonged hypoglycemia in...
17909707 - Adiponectin and the cardiovascular system: from risk to disease.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of clinical biochemistry     Volume:  28 ( Pt 5)     ISSN:  0004-5632     ISO Abbreviation:  Ann. Clin. Biochem.     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1991-12-30     Completed Date:  1991-12-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0324055     Medline TA:  Ann Clin Biochem     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  450-5     Citation Subset:  IM    
Affiliation:
Department of Medicine & Therapeutics, Aberdeen, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Albuminuria / diagnosis*
Creatinine / urine
Diabetes Mellitus, Type 1 / urine*
Diabetic Nephropathies / diagnosis
Humans
Middle Aged
Reproducibility of Results
Sensitivity and Specificity
Chemical
Reg. No./Substance:
60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The effect of a standard oral calcium load given in two different forms on plasma ionized calcium an...
Next Document:  Determination of kappa and lambda light chains in serum immunoglobulins G, A and M.