| A simple analytical method for determining the steady-state potential in models of geometrically complex neurons. | |
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MedLine Citation:
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PMID: 9700684 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A method is presented for solving the cable equation for a spiking neuron below firing threshold or a nonspiking neuron of arbitrary geometry under constant stimulation. The neuron structure is considered as a tree composed of a set of cylinder cables of three types (terminal, intermediate and branching) characterized by their lengths, diameters and linear membrane properties. The stimulation can result from either a uniform conductance-change over a whole cable segment or a point injection of a current. Other special segments are considered (synapses, voltage clamp, lumped soma). Equations are given for replacing any segment with its Thévenin equivalent, i.e. resistance and electromotive force. The step by step use of these elementary equations allows one to find the Thévenin equivalent of the whole neuron and to determine the steady-state membrane potential at any point. |
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Authors:
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A Vermeulen; J P Rospars |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of neuroscience methods Volume: 82 ISSN: 0165-0270 ISO Abbreviation: J. Neurosci. Methods Publication Date: 1998 Aug |
Date Detail:
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Created Date: 1998-11-06 Completed Date: 1998-11-06 Revised Date: 2000-12-18 |
Medline Journal Info:
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Nlm Unique ID: 7905558 Medline TA: J Neurosci Methods Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 123-34 Citation Subset: IM |
Affiliation:
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Laboratoire de Biométrie, Institut National de la Recherche Agronomique, Versailles, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Data Interpretation, Statistical* Dendrites / physiology Electrophysiology / methods* Membrane Potentials / physiology Models, Neurological* Neurons / physiology*, ultrastructure |
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