Document Detail

The significance of virulence factors in Helicobacter pylori.
MedLine Citation:
PMID:  23452293     Owner:  NLM     Status:  MEDLINE    
Helicobacter pylori (H. pylori) infection is linked to various gastroduodenal diseases; however, only a small fraction of these patients develop associated diseases. Despite the high prevalence of H. pylori infection in Africa and South Asia, the incidence of gastric cancer in these areas is much lower than those in other countries. The incidence of gastric cancer tends to decrease from north to south in East Asia. Such geographical differences in the pathology can be explained, at least in part, by the presence of different types of H. pylori virulence factors in addition to host and environmental factors. Virulence factors of H. pylori, such as CagA, VacA, DupA, IceA, OipA and BabA, have been demonstrated to be the predictors of severe clinical outcomes. Interestingly, a meta-analysis showed that CagA seropositivity was associated with gastric cancer compared with gastritis, even in East Asian countries where almost the strains possess cagA. Another meta-analysis also confirmed the significance of vacA, dupA and iceA. However, it is possible that additional important pathogenic genes may exist because H. pylori consists of approximately 1600 genes. Despite the advances in our understanding of the development of H. pylori infection-related diseases, further work is required to clarify the roles of H. pylori virulence factors.
Seiji Shiota; Rumiko Suzuki; Yoshio Yamaoka
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Journal of digestive diseases     Volume:  14     ISSN:  1751-2980     ISO Abbreviation:  J Dig Dis     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-05-28     Completed Date:  2014-01-27     Revised Date:  2014-07-02    
Medline Journal Info:
Nlm Unique ID:  101302699     Medline TA:  J Dig Dis     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  341-9     Citation Subset:  IM    
Copyright Information:
© 2013 The Authors. Journal of Digestive Diseases © 2013 Wiley Publishing Asia Pty Ltd and Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine.
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MeSH Terms
Bacterial Proteins / genetics
Genes, Bacterial
Helicobacter Infections / complications*,  microbiology
Helicobacter pylori / genetics,  pathogenicity*
Stomach Neoplasms / microbiology
Virulence / genetics
Virulence Factors / genetics*
Grant Support
Reg. No./Substance:
0/Bacterial Proteins; 0/Virulence Factors

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