Document Detail


The significance of thyroid-stimulating antibody (TSAb) in the management and prognostic evaluation of Graves disease.
MedLine Citation:
PMID:  2863805     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sixty six patients with Graves disease were followed up for the presence of TSAb at intervals of 4 to 12 weeks. Three different assays, the competitive TSH membrane-receptor assay (MRA), the cAMP-assay and the colloid droplet assay (CD) were used in parallel for demonstration of the antibody. In 17 of the patients TSAb was demonstrable also during remissions. 11 of these patients relapsed within a year. TSAb-positivity decline 1 to 4 months after 131I treatment. In case of persisting TSAb positivity 131I therapy or surgery should be given preference to thyrostatic medication. In gravidae followed up for TSAb, positivity not only persisted throughout pregnancy but even increased during the last trimester. After delivery all patients relapsed. One of the gravidae died of pregnancy toxicosis, the infant of another woman was thyrotoxic at birth. In pregnant women who have Graves disease and are positive for TSAb, thyrostatic or surgical treatment is recommended after the 2nd trimester even in cases of minor severity.
Authors:
A Leövey; K Kálmán; G Bakó; T Szabó
Related Documents :
9575645 - A study on some immunological parameters in infants with salmonellosis.
24323125 - Effect of interstimulus interval and age on cortical auditory evoked potentials in 10-2...
23175885 - Implementing the new who guidelines for the early detection of sensorineural hearing lo...
3415295 - Congenital hypothyroidism: increased incidence in asian families.
22844975 - A preterm infant with anaemia and left leg mild hemihypertrophy.
15906725 - Urinary iodide levels in term newborns and their mothers--a pilot study.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta medica Hungarica     Volume:  42     ISSN:  0236-5286     ISO Abbreviation:  Acta Med Hung     Publication Date:  1985  
Date Detail:
Created Date:  1985-10-21     Completed Date:  1985-10-21     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8400269     Medline TA:  Acta Med Hung     Country:  HUNGARY    
Other Details:
Languages:  eng     Pagination:  3-11     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antibodies / analysis*
Female
Graves Disease / immunology*,  therapy
Humans
Immunoglobulins, Thyroid-Stimulating
Iodine Radioisotopes / therapeutic use
Male
Middle Aged
Pregnancy
Pregnancy Complications / immunology
Prognosis
Receptors, Cell Surface / analysis
Receptors, Thyrotropin
Thyroid Gland / immunology*
Chemical
Reg. No./Substance:
0/Antibodies; 0/Immunoglobulins, Thyroid-Stimulating; 0/Iodine Radioisotopes; 0/Receptors, Cell Surface; 0/Receptors, Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Risk factors for retrolental fibroplasia: experience with 3,025 premature infants. National Collabor...
Next Document:  Initial treatment of adult patients with essential hypertension: I. Why conventional stepped-care th...