| The significance of thyroid blood flow at the inferior thyroid artery as a predictor for early Graves' disease relapse. | |
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MedLine Citation:
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PMID: 16343100 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We investigated the clinical usefulness of thyroid blood-flow measurement in predicting relapse of Graves' disease (GD) in comparison with known risk factors for GD relapse. MEASUREMENT: Thyroid blood flow was measured in pulsed Doppler mode at the inferior thyroid artery (ITA), and the peak systolic velocity (PSV) calculated. PATIENTS: ITA-PSV was measured in euthyroid GD patients (n = 79) immediately before withdrawal of anti-thyroid drug (ATD) and in healthy subjects (n = 17). RESULTS: In the 79 euthyroid GD patients, the values of free triiodothyronine (FT3), TSH receptor autoantibody (TRAb), ITA-PSV and thyroid volume were significantly higher in the relapse group (n = 40) than in the nonrelapse group (n = 39) and the Youden index of ITA-PSV was significantly higher than that of FT3, TSH, TRAb and vascular endothelial growth factor (VEGF). CONCLUSION: ITA-PSV may assist in the prediction of early GD relapse after ATD withdrawal. |
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Authors:
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Misako Ueda; Masaaki Inaba; Yasuro Kumeda; Toshiki Nagasaki; Yoshikazu Hiura; Hideki Tahara; Naoyoshi Onoda; Tetsuro Ishikawa; Yoshiki Nishizawa |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical endocrinology Volume: 63 ISSN: 0300-0664 ISO Abbreviation: Clin. Endocrinol. (Oxf) Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-12-13 Completed Date: 2006-02-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0346653 Medline TA: Clin Endocrinol (Oxf) Country: England |
Other Details:
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Languages: eng Pagination: 657-62 Citation Subset: IM |
Affiliation:
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Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Arteries / ultrasonography Autoantibodies / blood Case-Control Studies Female Graves Disease / blood, diagnosis*, physiopathology Humans Male Middle Aged Organ Size Predictive Value of Tests ROC Curve Receptors, Thyrotropin / immunology Recurrence Regional Blood Flow Thyroid Gland / blood supply*, pathology Triiodothyronine / blood Ultrasonography, Doppler, Pulsed Vascular Endothelial Growth Factor A / blood |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Receptors, Thyrotropin; 0/Vascular Endothelial Growth Factor A; 6893-02-3/Triiodothyronine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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