Document Detail

The significance of functioning gallbladder visualization on hepatobiliary scintigraphy in infants with persistent jaundice.
MedLine Citation:
PMID:  10914911     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to determine whether gallbladder visualization can help exclude biliary atresia in hepatobiliary scintigraphic studies of infants with persistent jaundice. METHODS: One hundred fifty-two infants with persistent jaundice (49 patients with a final diagnosis of biliary atresia and 103 with biliary patency) were studied using both hepatobiliary scintigraphy and abdominal sonography. Food was withheld for 4 h before the examination, and the infants were fed nothing but glucose until 6 h after the initial injection of (99m)Tc-disofenin or until the gallbladder was seen. If the gallbladder was seen, the infants were fed milk, and imaging was continued to observe gallbladder contractility. RESULTS: In none of the 49 patients with biliary atresia could the gallbladder be seen with hepatobiliary scintigraphy, but abdominal sonography revealed 9 normal-sized gallbladders. Of the 103 patients with biliary patency, hepatobiliary scintigraphy detected the gallbladder more frequently (74%, 76/103) than did abdominal sonography (63%, 65/103). All visualized gallbladders contracted after the infants were fed milk. If we include visualization of both the gallbladder and bowel radioactivity as criteria, the specificity of biliary atresia on hepatobiliary scintigraphy increases to 86% (89/103). CONCLUSION: Gallbladders were usually visible on hepatobiliary scintigraphy of fasting patients with biliary patency. A functioning gallbladder, with or without visualization of bowel radioactivity, indicated biliary patency.
C H Lee; P W Wang; T T Lee; M M Tiao; F C Huang; J H Chuang; C S Shieh; Y F Cheng
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  41     ISSN:  0161-5505     ISO Abbreviation:  J. Nucl. Med.     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-08-15     Completed Date:  2000-08-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1209-13     Citation Subset:  IM    
Department of Nuclear Medicine, Chang Gung Memorial Hospital, Chang Gung University, Kaohsiung, Taiwan, Republic of China.
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MeSH Terms
Biliary Atresia / complications,  radionuclide imaging,  ultrasonography
Gallbladder / radionuclide imaging*,  ultrasonography
Infant, Newborn
Jaundice, Neonatal / etiology,  radionuclide imaging*,  ultrasonography
Liver / radionuclide imaging*
Radiopharmaceuticals / diagnostic use
Technetium Tc 99m Disofenin / diagnostic use
Reg. No./Substance:
0/Radiopharmaceuticals; 0/Technetium Tc 99m Disofenin

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