| The significance of focal global sclerosis in idiopathic nephrotic syndrome. Long-term clinical observations. | |
| | |
MedLine Citation:
|
PMID: 4090967 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The clinical course of five pediatric patients with idiopathic nephrotic syndrome associated with focal global sclerosis in renal biopsy was analyzed retrospectively. The condition was defined as complete obsolescence of more than 15% of glomeruli associated with tubular atrophy and interstitial fibrosis. At onset, all children had a steroid-sensitive relapsing nephrotic syndrome. Two became steroid-dependent and one steroid-resistant. Cyclophosphamide or chlorambucil treatment was initially followed by remission in all patients; a second course was successful in one of two patients. After 12 to 18 years of observation, four patients are in remission for periods of 2 to 12 years. Glomerular filtration rate is slightly reduced in only one patient. This study suggests that the clinical course of children with idiopathic nephrotic syndrome associated with focal global sclerosis is similar to that observed in patients with minimal glomerular changes but different from that in patients with focal segmental sclerosis. |
| | |
Authors:
|
U Querfeld; R Waldherr; K Schärer |
Related Documents
:
|
20740617 - Safety and efficacy of rituximab in nonviral cryoglobulinemia vasculitis: data from the... 22842507 - The pharmacists' role in patient-provider pain management treatment agreements. 10334347 - The treatment of refractory uveitis with intravenous immunoglobulin. 22891997 - An evidence-based medical visit for patients with rheumatoid arthritis based on standar... 3317607 - Gram-negative bacterial pneumonia in the immunocompromised host. 7065747 - The clinical and pathologic correlations in mechanical biliary obstruction and acute ch... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Acta paediatrica Scandinavica Volume: 74 ISSN: 0001-656X ISO Abbreviation: Acta Paediatr Scand Publication Date: 1985 Nov |
Date Detail:
|
Created Date: 1986-03-13 Completed Date: 1986-03-13 Revised Date: 2009-11-11 |
Medline Journal Info:
|
Nlm Unique ID: 0000211 Medline TA: Acta Paediatr Scand Country: SWEDEN |
Other Details:
|
Languages: eng Pagination: 913-9 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antineoplastic Agents
/
therapeutic use Child Child, Preschool Humans Infant Kidney / pathology* Nephrotic Syndrome / drug therapy, pathology* Prognosis Retrospective Studies Sclerosis |
| Chemical | |
Reg. No./Substance:
|
0/Antineoplastic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Physical activity and sports involvement in 8- and 13-year-old children in Sweden.
Next Document: Blood pressure responses to care procedures in ventilated preterm infants.