Document Detail

The significance of the extracellular matrix in intracranial aneurysms.
MedLine Citation:
PMID:  7681275     Owner:  NLM     Status:  MEDLINE    
To what extent might change sin the extracellular matrix proteins in intracranial aneurysms (IA) or parent artery (PA) wall contribute to enlargement? Using IA specimens obtained from the coroner's office, the wall structure by light (Trichrome and Actin stains) and immunofluorescent microscopy (IF) (collagen I and fibronectin) have been studied in 18 specimens. It is well known that IA only arise when there is a deficiency in the internal elastic membrane and some breakdown in the media. The results show a normal three layer structure of intima, media, (muscularis), and adventitia in the PA extending out into the neck of the aneurysm. Immunofluorescent stains (IS) show collagen I and fibronectin limited to the adventitia and muscularis, respectively, of the PA and control arteries. The enlarging IA wall shows almost complete loss of this architecture. By IF stain, collagen I and fibronectin are intermingled throughout the IA wall. It is postulated that loss of structure and the confining muscularis layer permit easier elastic enlargement from a more or less homogeneous wall structure.
G Austin; S Fisher; D Dickson; D Anderson; S Richardson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of clinical and laboratory science     Volume:  23     ISSN:  0091-7370     ISO Abbreviation:  Ann. Clin. Lab. Sci.     Publication Date:    1993 Mar-Apr
Date Detail:
Created Date:  1993-04-22     Completed Date:  1993-04-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0410247     Medline TA:  Ann Clin Lab Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  97-105     Citation Subset:  IM    
Aneurysm Research Laboratory, University of California, Santa Barbara.
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MeSH Terms
Actins / metabolism
Cerebral Arteries / metabolism,  pathology
Collagen / metabolism
Endothelium, Vascular / metabolism
Extracellular Matrix / physiology*
Fibronectins / metabolism
Fluorescent Antibody Technique
Intracranial Aneurysm / metabolism,  pathology*
Muscle, Smooth, Vascular / pathology
Staining and Labeling
Reg. No./Substance:
0/Actins; 0/Fibronectins; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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