| The significance of the extracellular matrix in intracranial aneurysms. | |
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MedLine Citation:
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PMID: 7681275 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To what extent might change sin the extracellular matrix proteins in intracranial aneurysms (IA) or parent artery (PA) wall contribute to enlargement? Using IA specimens obtained from the coroner's office, the wall structure by light (Trichrome and Actin stains) and immunofluorescent microscopy (IF) (collagen I and fibronectin) have been studied in 18 specimens. It is well known that IA only arise when there is a deficiency in the internal elastic membrane and some breakdown in the media. The results show a normal three layer structure of intima, media, (muscularis), and adventitia in the PA extending out into the neck of the aneurysm. Immunofluorescent stains (IS) show collagen I and fibronectin limited to the adventitia and muscularis, respectively, of the PA and control arteries. The enlarging IA wall shows almost complete loss of this architecture. By IF stain, collagen I and fibronectin are intermingled throughout the IA wall. It is postulated that loss of structure and the confining muscularis layer permit easier elastic enlargement from a more or less homogeneous wall structure. |
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Authors:
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G Austin; S Fisher; D Dickson; D Anderson; S Richardson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of clinical and laboratory science Volume: 23 ISSN: 0091-7370 ISO Abbreviation: Ann. Clin. Lab. Sci. Publication Date: 1993 Mar-Apr |
Date Detail:
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Created Date: 1993-04-22 Completed Date: 1993-04-22 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0410247 Medline TA: Ann Clin Lab Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 97-105 Citation Subset: IM |
Affiliation:
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Aneurysm Research Laboratory, University of California, Santa Barbara. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Actins
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metabolism Cerebral Arteries / metabolism, pathology Collagen / metabolism Endothelium, Vascular / metabolism Extracellular Matrix / physiology* Fibronectins / metabolism Fluorescent Antibody Technique Humans Intracranial Aneurysm / metabolism, pathology* Muscle, Smooth, Vascular / pathology Staining and Labeling |
| Chemical | |
Reg. No./Substance:
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0/Actins; 0/Fibronectins; 9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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