Document Detail


The significance of circadian organization for longevity in the golden hamster.
MedLine Citation:
PMID:  9783234     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
While functional roles for biological clocks have been demonstrated in organisms throughout phylogeny, the adaptive advantages of circadian organization per se are largely matters of conjecture. It is generally accepted, though without direct experimental evidence, that organisms derive primary benefits from the temporal organization of their physiology and behavior, as well as from the anticipation of daily changes in their environment and their own fluctuating physiological requirements. However, the consequences of circadian dysfunction that might demonstrate a primary adaptive advantage and explain the natural origins and apparent ubiquity of circadian systems have not been documented. The authors report that longevity in hamsters is decreased with a noninvasive disruption of rhythmicity and is increased in older animals given suprachiasmatic implants that restore higher amplitude rhythms. The results substantiate the importance of the temporal organization of physiology and behavior provided by the circadian clock to the health and longevity of an organism.
Authors:
M W Hurd; M R Ralph
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of biological rhythms     Volume:  13     ISSN:  0748-7304     ISO Abbreviation:  J. Biol. Rhythms     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1998-12-18     Completed Date:  1998-12-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8700115     Medline TA:  J Biol Rhythms     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  430-6     Citation Subset:  IM    
Affiliation:
Department of Biology, University of Houston, TX 77204-5513, USA.
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology
Animals
Circadian Rhythm / physiology*
Cricetinae
Environment
Fetal Tissue Transplantation
Longevity / physiology*
Mesocricetus / physiology*
Motor Activity / physiology
Suprachiasmatic Nucleus / physiology,  transplantation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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